| Successful Alternative Treatment Containing Vindesine for Acute Lymphoblastic Leukemia With Charcot-Marie-Tooth Disease. | |
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MedLine Citation:
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PMID: 22246157 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Peripheral neuropathy is a well-known side effect of vincristine (VCR), a microtubule inhibitor commonly used to treat malignancies. Severe neurological adverse events can occur in patients with Charcot-Marie-Tooth disease (CMT) treated with VCR. Vindesine is also a microtubule inhibitor, which, like VCR, is widely used to treat malignancies. The case of an 11-year-old female patient with CMT type 1A who developed severe peripheral neuropathy induced by VCR given for her acute lymphoblastic leukemia is reported. Alternative treatment containing vindesine instead of VCR led to a successful outcome without a relapse of leukemia or neurological worsening of CMT. |
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Authors:
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Mizuho Ichikawa; Daisuke Suzuki; Jun Inamoto; Junjiro Ohshima; Yuko Cho; Shinji Saitoh; Makoto Kaneda; Akihiro Iguchi; Tadashi Ariga |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: - ISSN: 1536-3678 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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*Department of Pediatrics, Hokkaido University Graduate School of Medicine †Department of Pediatrics, Sapporo Hokuyu Hospital, Sapporo ‡Department of Pediatrics, Asahikawa Medical College, Asahikawa, Hokkaido, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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