Document Detail

Success rate of repeated fine needle aspiration biopsy of clinically suspicious thyroid nodules.
MedLine Citation:
PMID:  22552740     Owner:  NLM     Status:  MEDLINE    
AIM: The success rate of FNAB in clinical setting is quite low. There were several attempts made to improve the success rate of this method. It is anticipated that a double FNAB in one session would increase the success rate of FNAB.
PATIENTS, METHODS: 176 consecutive patients (130 women, 46 men; mean age 56 years ± 11) with at least one clinically suspicious nodule were included in this study. Each individual nodule was biopsied twice (20G- and 21G-needle). In 33 patients, two suspicious nodules were biopsied, accounting for a total of 209 biopsied thyroid nodules. To evaluate the success rate the number of cell formations and the total number of cells in each cell formation were counted.
RESULTS: The biopsy with the 20G needle provided in mean 40 cell cluster with a mean of 830 cells whereas the 21G needle provided in mean 41 cell cluster with a mean of 1010 cells. With the 20G needle the success rate was 73%, with the 21G needle 78% and the combination of the both biopsies provided a success rate of 87% (p = 0.01). Based on the number of cell formations and the total number of cells, the difference between the two needle sizes was not significant (p = 0.5 for cell formations and p = 0.9 for the total number of cells, respectively).
CONCLUSION: A double FNAB of suspicious thyroid nodules in one session provides a higher success rate, and a 21G needle is sufficient enough.
J Nagarajah; J Farahati; R Görges; F Grabellus; A Bockisch; S-Y Sheu-Grabellus
Publication Detail:
Type:  Journal Article     Date:  2012-05-03
Journal Detail:
Title:  Nuklearmedizin. Nuclear medicine     Volume:  51     ISSN:  0029-5566     ISO Abbreviation:  Nuklearmedizin     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-06     Completed Date:  2013-01-18     Revised Date:  2013-04-22    
Medline Journal Info:
Nlm Unique ID:  7609387     Medline TA:  Nuklearmedizin     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  116-8     Citation Subset:  IM    
Klinik für Nuklearmedizin, Universität Duisburg-Essen, Essen, Germany.
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MeSH Terms
Biopsy, Fine-Needle / statistics & numerical data*
Germany / epidemiology
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Thyroid Nodule / epidemiology*,  pathology*
Comment In:
Nuklearmedizin. 2012;51(5):N47; author reply N47   [PMID:  23494110 ]

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