Document Detail


Success rates of trabeculotomy for steroid-induced glaucoma: a comparative, multicenter, retrospective cohort study.
MedLine Citation:
PMID:  21396622     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the surgical outcomes of trabeculotomy for steroid-induced glaucoma.
DESIGN: Multicenter, retrospective cohort study.
METHODS: At 17 Japanese clinical centers, 121 steroid-induced glaucoma patients who underwent trabeculotomy between 1997 and 2006 were reviewed. Surgical failure was defined by the need for additional glaucoma surgery, deterioration of visual acuity to no light perception, or intraocular pressure ≥21 mm Hg (criterion A) and ≥18 mm Hg (criterion B). Surgical outcomes were compared with those of 108 primary open-angle glaucoma (POAG) patients who underwent trabeculotomy and 42 steroid-induced glaucoma patients who underwent trabeculectomy. Prognostic factors for failure were evaluated using the Cox proportional hazards model.
RESULTS: The probabilities of success at 3 years for trabeculotomy for steroid-induced glaucoma vs trabeculotomy for POAG was 78.1% vs 55.8% for criterion A (P = .0008) and 56.4% vs 30.6% for criterion B (P < .0001), respectively. At 3 years, the success of trabeculotomy for steroid-induced glaucoma was comparable to trabeculectomy for steroid-induced glaucoma for criterion A (83.8%; P = .3636), but lower for criterion B (71.6%; P = .0352). Prognostic factors for failure of trabeculotomy for steroid-induced glaucoma were previous vitrectomy (relative risk [RR] = 5.340; P = .0452 on criterion A, RR = 3.898; P = .0360 for criterion B) and corticosteroid administration other than ocular instillation (RR = 2.752; P = .0352 for criterion B).
CONCLUSIONS: Trabeculotomy is effective for controlling intraocular pressure <21 mm Hg in steroid-induced glaucoma eyes.
Authors:
Keiichiro Iwao; Masaru Inatani; Hidenobu Tanihara;
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2011-03-10
Journal Detail:
Title:  American journal of ophthalmology     Volume:  151     ISSN:  1879-1891     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-27     Completed Date:  2011-07-27     Revised Date:  2011-09-30    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1047-1056.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alkylating Agents / administration & dosage
Cohort Studies
Female
Glaucoma, Open-Angle / chemically induced*,  physiopathology,  surgery*
Glucocorticoids / adverse effects*
Humans
Intraocular Pressure / physiology
Male
Middle Aged
Mitomycin
Probability
Retrospective Studies
Trabeculectomy*
Treatment Outcome
Visual Acuity / physiology
Chemical
Reg. No./Substance:
0/Alkylating Agents; 0/Glucocorticoids; 50-07-7/Mitomycin
Investigator
Investigator/Affiliation:
Keiichiro Iwao / ; Masaru Inatani / ; Hidenobu Tanihara / ; Keiichiro Iwao / ; Shinichiro Ishikawa / ; Satoshi Okinami / ; Takayuki Tanaka / ; Takeo Fukuchi / ; Makiko Ito / ; Toshikatsu Kaburaki / ; Eiji Murotani / ; Tomomi Higashide / ; Kyoko Ishida / ; Tetsuya Yamamoto / ; Kazuyuki Hirooka / ; Fumio Shiraga / ; Kiyotaka Ishijima / ; Kenji Kashiwagi / ; Toru Nakazawa / ; Nobuo Fuse / ; Eriko Tomoyose / ; Hiroshi Sakai / ; Yoko Ikeda / ; Kazuhiko Mori / ; Takehiro Yamashita / ; Taiji Sakamoto / ; Fumitaka Hirose / ; Masanori Hangai / ; Miho Nozaki / ; Yuichiro Ogura / ; Maiko Naka / ; Akira Negi / ; Mina Mizukami / ; Takashi Kanamoto / ; Ryusuke Futa /
Comments/Corrections
Comment In:
Am J Ophthalmol. 2011 Sep;152(3):503; author reply 504   [PMID:  21855678 ]
Am J Ophthalmol. 2011 Sep;152(3):502; author reply 502-3   [PMID:  21855676 ]

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