Document Detail

Subversion of cytokine networks by virally encoded decoy receptors.
MedLine Citation:
PMID:  23046131     Owner:  NLM     Status:  MEDLINE    
During the course of evolution, viruses have captured or created a diverse array of open reading frames, which encode for proteins that serve to evade and sabotage the host innate and adaptive immune responses that would otherwise lead to their elimination. These viral genomes are some of the best textbooks of immunology ever written. The established arsenal of immunomodulatory proteins encoded by viruses is large and growing, and includes specificities for virtually all known inflammatory pathways and targets. The focus of this review is on herpes and poxvirus-encoded cytokine and chemokine-binding proteins that serve to undermine the coordination of host immune surveillance. Structural and mechanistic studies of these decoy receptors have provided a wealth of information, not only about viral pathogenesis but also about the inner workings of cytokine signaling networks.
Megan L Epperson; Chung A Lee; Daved H Fremont
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  250     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-02-25     Revised Date:  2014-11-09    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  199-215     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
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MeSH Terms
Chemokines / chemistry*,  immunology,  metabolism
Herpesviridae / chemistry,  immunology*
Herpesviridae Infections / immunology,  virology
Host-Pathogen Interactions
Immune Evasion*
Immunologic Surveillance
Molecular Mimicry / immunology
Poxviridae / chemistry,  immunology*
Poxviridae Infections / immunology,  virology
Receptors, Chemokine / chemistry*,  immunology,  metabolism
Receptors, Virus / chemistry*,  immunology,  metabolism
Signal Transduction
Viral Proteins / chemistry*,  immunology,  metabolism
Grant Support
HHSN272200700058C/AI/NIAID NIH HHS; HHSN272200700058C//PHS HHS; HHSN272201200026C/AI/NIAID NIH HHS; HHSN272201200026C//PHS HHS; R01 AI073552/AI/NIAID NIH HHS; R01 AI073552/AI/NIAID NIH HHS; T32 CA009547/CA/NCI NIH HHS; U54 AI057160/AI/NIAID NIH HHS; U54 AI057160/AI/NIAID NIH HHS
Reg. No./Substance:
0/Chemokines; 0/Receptors, Chemokine; 0/Receptors, Virus; 0/Viral Proteins

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