Document Detail


Subversion of cellular functions by Listeria monocytogenes.
MedLine Citation:
PMID:  16362984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Listeria monocytogenes is a Gram-positive bacterium that is able to invade and multiply within eukaryotic cells. Its intracellular life-cycle includes pathogen-induced phagocytosis, lysis of the phagocytic vacuole, movement in the cytoplasmic environment, and a cell-to-cell spread mechanism. Many L. monocytogenes virulence factors have been studied in detail, certain of which subvert specific eukaryotic cell functions in order to favour infection. During entry, the invasion protein InlA takes advantage of the adhesion molecule E-cadherin and the adherens junction machinery to adhere to target and invade polarized epithelial cells. Another invasion protein of the internalin family, InlB, subverts the signalling pathway of the hepatocyte growth factor receptor Met to induce endocytosis of the receptor and also to favour internalization of the bacteria in non-polarized epithelial cells. Once inside the cell, the haemolysin of L. monocytogenes--the listeriolysin O or LLO--is secreted to lyse the phagocytic vacuole, and when the bacteria is freed in the cytoplasm, the activity of the LLO is in part regulated by the infected cell itself, taking advantage of the pH sensitivity of the LLO that leads to its inactivation in the neutral eukaryotic cell cytoplasm. Finally, to induce bacterial movement in the cytoplasm, the L. monocytogenes surface protein ActA mimics the activity of the eukaryotic WASP family of proteins to recruit to the bacteria the actin nucleation machinery required for actin polymerization and for the formation of the actin structures (called 'actin comet tails') that propel the parasite in the cytosol and help it to invade neighbouring cells.
Authors:
Javier Pizarro-Cerdá; Pascale Cossart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of pathology     Volume:  208     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-23     Completed Date:  2006-03-06     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  215-23     Citation Subset:  IM    
Copyright Information:
Copyright 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Affiliation:
Unité des Interactions Bactéries-Cellules/INSERM U604/INRA USC2020, Institut Pasteur, Paris, France. pizarroj@pasteur.fr
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MeSH Terms
Descriptor/Qualifier:
Bacterial Proteins / physiology
Bacterial Toxins
Eukaryotic Cells / physiology*
Heat-Shock Proteins / physiology
Hemolysin Proteins
Humans
Hydrogen-Ion Concentration
Listeria monocytogenes / physiology*
Listeriosis / microbiology,  physiopathology
Membrane Proteins / physiology
Proto-Oncogene Proteins / physiology
Proto-Oncogene Proteins c-met
Receptors, Growth Factor / physiology
Vacuoles / microbiology
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Bacterial Toxins; 0/Heat-Shock Proteins; 0/Hemolysin Proteins; 0/Membrane Proteins; 0/Proto-Oncogene Proteins; 0/Receptors, Growth Factor; 0/inlB protein, Listeria monocytogenes; 139948-71-3/internalin protein, Bacteria; 144430-05-7/actA protein, Listeria monocytogenes; 72270-41-8/hlyA protein, Listeria monocytogenes; EC 2.7.10.1/MET protein, human; EC 2.7.10.1/Proto-Oncogene Proteins c-met

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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