| Subversion of cellular functions by Listeria monocytogenes. | |
| | |
MedLine Citation:
|
PMID: 16362984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Listeria monocytogenes is a Gram-positive bacterium that is able to invade and multiply within eukaryotic cells. Its intracellular life-cycle includes pathogen-induced phagocytosis, lysis of the phagocytic vacuole, movement in the cytoplasmic environment, and a cell-to-cell spread mechanism. Many L. monocytogenes virulence factors have been studied in detail, certain of which subvert specific eukaryotic cell functions in order to favour infection. During entry, the invasion protein InlA takes advantage of the adhesion molecule E-cadherin and the adherens junction machinery to adhere to target and invade polarized epithelial cells. Another invasion protein of the internalin family, InlB, subverts the signalling pathway of the hepatocyte growth factor receptor Met to induce endocytosis of the receptor and also to favour internalization of the bacteria in non-polarized epithelial cells. Once inside the cell, the haemolysin of L. monocytogenes--the listeriolysin O or LLO--is secreted to lyse the phagocytic vacuole, and when the bacteria is freed in the cytoplasm, the activity of the LLO is in part regulated by the infected cell itself, taking advantage of the pH sensitivity of the LLO that leads to its inactivation in the neutral eukaryotic cell cytoplasm. Finally, to induce bacterial movement in the cytoplasm, the L. monocytogenes surface protein ActA mimics the activity of the eukaryotic WASP family of proteins to recruit to the bacteria the actin nucleation machinery required for actin polymerization and for the formation of the actin structures (called 'actin comet tails') that propel the parasite in the cytosol and help it to invade neighbouring cells. |
| | |
Authors:
|
Javier Pizarro-Cerdá; Pascale Cossart |
Related Documents
:
|
11155164 - Adherence of porphyromonas gingivalis to gingival epithelial cells: modulation of bacte... 10030544 - The effect of cigarette smoke on adherence of respiratory pathogens to buccal epithelia... 2919724 - The role of phospholipase in host cell penetration by toxoplasma gondii. 9251204 - Separation of bacterial cells by isoelectric focusing, a new method for analysis of com... 22304344 - Cytotoxic angucycline class glycosides from the deep sea actinomycete streptomyces lusi... 12232364 - Cytoplasmic acidification and secondary metabolite production in different plant cell s... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: The Journal of pathology Volume: 208 ISSN: 0022-3417 ISO Abbreviation: J. Pathol. Publication Date: 2006 Jan |
Date Detail:
|
Created Date: 2005-12-23 Completed Date: 2006-03-06 Revised Date: 2012-06-04 |
Medline Journal Info:
|
Nlm Unique ID: 0204634 Medline TA: J Pathol Country: England |
Other Details:
|
Languages: eng Pagination: 215-23 Citation Subset: IM |
Copyright Information:
|
Copyright 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
Affiliation:
|
Unité des Interactions Bactéries-Cellules/INSERM U604/INRA USC2020, Institut Pasteur, Paris, France. pizarroj@pasteur.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bacterial Proteins
/
physiology Bacterial Toxins Eukaryotic Cells / physiology* Heat-Shock Proteins / physiology Hemolysin Proteins Humans Hydrogen-Ion Concentration Listeria monocytogenes / physiology* Listeriosis / microbiology, physiopathology Membrane Proteins / physiology Proto-Oncogene Proteins / physiology Proto-Oncogene Proteins c-met Receptors, Growth Factor / physiology Vacuoles / microbiology |
| Chemical | |
Reg. No./Substance:
|
0/Bacterial Proteins; 0/Bacterial Toxins; 0/Heat-Shock Proteins; 0/Hemolysin Proteins; 0/Membrane Proteins; 0/Proto-Oncogene Proteins; 0/Receptors, Growth Factor; 0/inlB protein, Listeria monocytogenes; 139948-71-3/internalin protein, Bacteria; 144430-05-7/actA protein, Listeria monocytogenes; 72270-41-8/hlyA protein, Listeria monocytogenes; EC 2.7.10.1/MET protein, human; EC 2.7.10.1/Proto-Oncogene Proteins c-met |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pathogenesis and prevalence of variant Creutzfeldt-Jakob disease.
Next Document: The function of immunoglobulin A in immunity.