Document Detail

Subversion of the actin cytoskeleton during viral infection.
MedLine Citation:
PMID:  21522191     Owner:  NLM     Status:  MEDLINE    
Viral infection converts the normal functions of a cell to optimize viral replication and virion production. One striking observation of this conversion is the reconfiguration and reorganization of cellular actin, affecting every stage of the viral life cycle, from entry through assembly to egress. The extent and degree of cytoskeletal reorganization varies among different viral infections, suggesting the evolution of myriad viral strategies. In this Review, we describe how the interaction of viral proteins with the cell modulates the structure and function of the actin cytoskeleton to initiate, sustain and spread infections. The molecular biology of such interactions continues to engage virologists in their quest to understand viral replication and informs cell biologists about the role of the cytoskeleton in the uninfected cell.
Matthew P Taylor; Orkide O Koyuncu; Lynn W Enquist
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-04-27
Journal Detail:
Title:  Nature reviews. Microbiology     Volume:  9     ISSN:  1740-1534     ISO Abbreviation:  Nat. Rev. Microbiol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-16     Completed Date:  2011-08-01     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  101190261     Medline TA:  Nat Rev Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  427-39     Citation Subset:  IM    
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MeSH Terms
Actins / chemistry,  metabolism*
Adenoviridae / physiology
Cell Transformation, Viral / physiology
Cytoskeleton / metabolism*
Endocytosis / physiology
Hepatitis B virus / physiology
Herpesviridae / physiology
Rous sarcoma virus / physiology
Simian virus 40 / physiology
Viral Proteins / metabolism
Virion / physiology
Virus Assembly
Virus Replication / physiology*
rho GTP-Binding Proteins / metabolism
Grant Support
R01 NS033506/NS/NINDS NIH HHS; R01 NS060699/NS/NINDS NIH HHS; R01 NS060699-03/NS/NINDS NIH HHS; R01 NS060699-03/NS/NINDS NIH HHS; R37 NS033506/NS/NINDS NIH HHS; R37 NS033506-16/NS/NINDS NIH HHS; R37 NS033506-16/NS/NINDS NIH HHS
Reg. No./Substance:
0/Actins; 0/Viral Proteins; EC GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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