Document Detail


Subunits of Tamm-Horsfall glycoprotein.
MedLine Citation:
PMID:  5441368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The effect of 6m-guanidine hydrochloride on the urinary glycoprotein described by Tamm & Horsfall (1952) is to produce a homogeneous subunit of molecular weight approx. 100000. 2. Complete reduction of the disulphide bonds of this subunit does not decrease the molecular weight, suggesting that all disulphide bonds are intrachain. 3. Comparison of sedimentation and viscometric behaviour of unreduced and reduced material in 6m-guanidine hydrochloride is consistent with reduction causing an opening-up of intrachain disulphide bonds to give a more asymmetric molecule.
Authors:
F K Stevenson; P W Kent
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  116     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1970 Mar 
Date Detail:
Created Date:  1970-06-15     Completed Date:  1970-06-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  791-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Chemical Phenomena
Chemistry
Electrophoresis
Glycoproteins / analysis*
Guanidines
Humans
Immune Sera
Male
Molecular Weight
Ultracentrifugation
Viscosity
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/Guanidines; 0/Immune Sera
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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