Document Detail


Subungual myxoid pleomorphic fibroma.
MedLine Citation:
PMID:  9790115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors report an example of pleomorphic fibroma in a unique site: the subungual space of the thumb. A 54-year-old man presented with paronychia and markedly thickened hyperkeratotic nail. The nail plate was removed, and an exophytic, red, friable, granulation tissue-like lesion was revealed subungually. The lesion was diagnosed clinically as pyogenic granuloma. Excisional biopsy was performed. Histologically, the lesion showed a hypocellular fibroma with myxoid areas and dilated blood vessels. Interspersed with ordinary appearing fibroblasts, there were bizarre, atypical fibroblasts with hyperchromatic and large, pleomorphic nuclei and multinucleated floret-like giant cells. These atypical cells showed strong immunoreactivity with antibodies against CD34 and vimentin. Occasional positivity was noted with factor XIIIa and alpha-1-antichymotrypsin, whereas no reactivity occurred with alpha-1-antitrypsin, actin, or S-100 protein. The entity of pleomorphic fibroma has been reported in many body sites; however, this is the first case to be reported in the subungual space.
Authors:
A Hassanein; G Telang; E Benedetto; R Spielvogel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  20     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-16     Completed Date:  1998-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  502-5     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Allegheny University of the Health Sciences (Hahnemann Campus), Philadelphia, Pennsylvania, USA.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD34 / analysis
Fibroma / chemistry,  pathology*
Humans
Immunohistochemistry
Male
Middle Aged
Nails / pathology*
Skin Neoplasms / chemistry,  pathology*
Thumb
Vimentin / analysis
Chemical
Reg. No./Substance:
0/Antigens, CD34; 0/Vimentin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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