Document Detail


Subungual keratoacanthoma: analysis of cell proliferation and copy number variation of oncogenes compared with periungual squamous cell carcinoma.
MedLine Citation:
PMID:  20456385     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background.  Subungual keratoacanthoma (SUKA) is a rare cutaneous tumour with several features distinct from ordinary KA. SUKA may not show spontaneous regression and sometimes grows progressively, resulting in phalangeal bone destruction. This makes its distinction from digital squamous cell carcinoma (SCC) difficult. Aim.  To investigate differences in molecular expression between SUKA and digital SCC. Methods.  In addition to immunohistochemical analysis of Ki-67, one of the markers differentiating KA from SCC, we investigated the copy numbers of various oncogenes by multiplex ligation-dependent probe amplification (MLPA) using two cases of SUKA and three cases of periungual SCC. Results.  Ki-67 was moderately or strongly positive in SCC but negative in SUKA. The MLPA analysis showed that the nuclear factor (NF)κB1 and cortactin (CTTN; formerly known as EMS1) genes are amplified in SUKA but not in digital SCC. This increase in NFκB1 was confirmed by immunohistochemical analysis. Conclusion.  NFκB1 could be a novel marker to differentiate between SUKA and SCC. Although this study was performed on limited numbers of patients with SUKA, MLPA analysis could be applied to differentiate other benign tumours from their malignant counterparts.
Authors:
M Honma; N Kato; M Hashimoto; H Takahashi; A Ishida-Yamamoto; H Iizuka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  36     ISSN:  1365-2230     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  57-62     Citation Subset:  IM    
Copyright Information:
© 2010 The Author(s). Journal compilation © 2010 British Association of Dermatologists.
Affiliation:
Department of Dermatology, Asahikawa Medical College, Asahikawa, Japan.
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