| Subtyping borderline nuclear changes: is it of value in predicting high-grade cervical intraepithelial neoplasia on histology? | |
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MedLine Citation:
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PMID: 14510887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim was to determine the association between the subtypes of borderline nuclear changes (BNC) in cervical smears and high-grade cervical intraepithelial neoplasia (HCIN). BNC was reported in 23236 smears received in our laboratory over a 7-year period, 3278 patients were referred for colposcopy. Analysis was restricted to 2007 cases, which fitted the criteria of: (1). consistent subtyping of borderline change and (2). cervical histology result within 12 months of the last abnormal smear. BNC was reported in six categories and correlated with histology. Atypia bordering on dyskaryosis, atypical metaplastic cells and endocervical atypia, were associated with HCIN in 25%, 25.4% and 23.8% of cases, respectively. Dyskeratosis and koilocytotic atypia were associated with HCIN in 19.2% and 13.7% of cases, respectively. Some subtypes of borderline change are more frequently associated with HCIN. The difference is not sufficient to dictate clinical management. |
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Authors:
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S Shanbhag; M Roberts; S J Johnson; V Wadehra |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cytopathology : official journal of the British Society for Clinical Cytology Volume: 14 ISSN: 0956-5507 ISO Abbreviation: Cytopathology Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-26 Completed Date: 2004-05-19 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9010345 Medline TA: Cytopathology Country: England |
Other Details:
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Languages: eng Pagination: 241-8 Citation Subset: IM |
Affiliation:
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Departments of Gynaecology Cellular Pathology (Cytology), Royal Victoria Infirmary, Newcastle-upon-Tyne, UK. s.shanbhag@abdn.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Nucleus
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pathology* Cervical Intraepithelial Neoplasia / classification, diagnosis* Female Humans Precancerous Conditions / classification, diagnosis* Predictive Value of Tests Retrospective Studies Uterine Cervical Neoplasms / classification, diagnosis* Vaginal Smears / methods* |
| Comments/Corrections | |
Comment In:
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Cytopathology. 2003 Oct;14(5):231-4
[PMID:
14510885
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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