Document Detail


Subtyping borderline nuclear changes: is it of value in predicting high-grade cervical intraepithelial neoplasia on histology?
MedLine Citation:
PMID:  14510887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim was to determine the association between the subtypes of borderline nuclear changes (BNC) in cervical smears and high-grade cervical intraepithelial neoplasia (HCIN). BNC was reported in 23236 smears received in our laboratory over a 7-year period, 3278 patients were referred for colposcopy. Analysis was restricted to 2007 cases, which fitted the criteria of: (1). consistent subtyping of borderline change and (2). cervical histology result within 12 months of the last abnormal smear. BNC was reported in six categories and correlated with histology. Atypia bordering on dyskaryosis, atypical metaplastic cells and endocervical atypia, were associated with HCIN in 25%, 25.4% and 23.8% of cases, respectively. Dyskeratosis and koilocytotic atypia were associated with HCIN in 19.2% and 13.7% of cases, respectively. Some subtypes of borderline change are more frequently associated with HCIN. The difference is not sufficient to dictate clinical management.
Authors:
S Shanbhag; M Roberts; S J Johnson; V Wadehra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytopathology : official journal of the British Society for Clinical Cytology     Volume:  14     ISSN:  0956-5507     ISO Abbreviation:  Cytopathology     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-26     Completed Date:  2004-05-19     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9010345     Medline TA:  Cytopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  241-8     Citation Subset:  IM    
Affiliation:
Departments of Gynaecology Cellular Pathology (Cytology), Royal Victoria Infirmary, Newcastle-upon-Tyne, UK. s.shanbhag@abdn.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Cell Nucleus / pathology*
Cervical Intraepithelial Neoplasia / classification,  diagnosis*
Female
Humans
Precancerous Conditions / classification,  diagnosis*
Predictive Value of Tests
Retrospective Studies
Uterine Cervical Neoplasms / classification,  diagnosis*
Vaginal Smears / methods*
Comments/Corrections
Comment In:
Cytopathology. 2003 Oct;14(5):231-4   [PMID:  14510885 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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