Document Detail

Subtypes of schizophrenia--evidence from a twin-family study.
MedLine Citation:
PMID:  1950618     Owner:  NLM     Status:  MEDLINE    
In a combined twin-family study, the concordance for subtype of schizophrenia was investigated. The sample included 31 monozygotic (MZ) and 28 dizygotic (DZ) twin probands fulfilling the criteria of DSM-III-R schizophrenia. Their co-twins and first-degree relatives were personally interviewed and diagnosed in accordance with DSM-III-R. Any twin or relative diagnosed as schizophrenic was subclassified as either paranoid or nonparanoid. Schizophrenia was more often observed in co-twins of MZ probands with nonparanoid schizophrenia than in MZ probands with paranoid schizophrenia, indicating a stronger genetic influence in nonparanoid schizophrenia. Fifteen MZ pairs were concordant for schizophrenia, and 13 of these pairs were also concordant for subtype. Such a relationship was not observed in the first-degree relatives with schizophrenia. Our results indicate a complex etiology of subtypes in schizophrenia, and to some extent the etiology of subtypes may differ from the etiology of schizophrenia.
S Onstad; I Skre; S Torgersen; E Kringlen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  84     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-17     Completed Date:  1991-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  203-6     Citation Subset:  IM    
Department of Psychiatry, University of Oslo, Norway.
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MeSH Terms
Diseases in Twins / genetics*,  psychology*
Middle Aged
Psychiatric Status Rating Scales
Schizophrenia / classification*,  diagnosis,  genetics*
Schizophrenia, Paranoid / diagnosis,  genetics,  psychology
Schizophrenic Psychology*

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