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Subtypes of irritable bowel syndrome on Rome III criteria : a multi-center study.
MedLine Citation:
PMID:  21929652     Owner:  NLM     Status:  Publisher    
Background and Aims: To explore the distribution and clinical characteristics of four subtypes of irritable bowel syndrome (IBS) based on Rome III criteria in Chinese. Methods: Consecutive 754 IBS outpatients from three tertiary hospitals in China were included. Diagnostic criteria were based on Rome II or Rome III. Results: Among 754 outpatients, 510(67.6%) patients met Rome II criteria, 735(97.5%) patients met Rome III criteria and 492(65.3%) patients met both criteria. Among 735 patients who met Rome III criteria, 66.3% were IBS with diarrhea (IBS-D), 14.7% were IBS with constipation (IBS-C), 4.2% were mixed IBS (IBS-M) and 14.8% were unsubtyped IBS (IBS-U). Most of IBS-D, IBS-C and IBS-M patients based on Rome III criteria matched to diarrhea-predominant IBS (D-IBS), constipation-predominant IBS (C-IBS) and alternating IBS(A-IBS) based on Rome II criteria respectively. Among IBS-U patients, 57.0%, 33.3% and 9.7% were C-IBS, D-IBS and A-IBS respectively. For IBS-M, the frequencies of bowel movements were stable in 48.4% patients and variable in 51.6% patients. Defecation urgency and straining were most frequent in IBS-M and least frequent in IBS-U patients than other subtypes. About 77.2% of IBS-U patients had abnormal stool frequency (<3/week or >3/day). Conclusion: Rome III criteria is more sensitive and practical in diagnosing IBS. IBS-D is the most frequent subtype, which is followed by IBS-U, IBS-C and IBS-M. IBS-U is a new subtype which warrants further studies.
Xin Yao; Yun Sheng Yang; Li Hong Cui; Ka Bing Zhao; Zhen Hua Zhang; Li Hua Peng; Xu Guo; Gang Sun; Jun Shang; Wei Feng Wang; Jia Feng; Qiyang Huang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-19
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing , Department of Gastroenterology, Naval General Hospital, Beijing and Department of Gastroenterology, Bethune International Peace Hospital, Shijiazhuang, China.
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