Document Detail

Subtraction CT with low-flow-rate arterial contrast injection to estimate drug distribution during balloon-occluded arterial chemotherapy infusion for bladder cancer.
MedLine Citation:
PMID:  10821894     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To simulate drug distribution during balloon-occluded arterial chemotherapy infusion (BOAI) for urinary bladder cancer using subtraction computed tomography (CT) with low-flow-rate arterial contrast injection (S-CTLA). METHODS: Ten patients with bladder cancer underwent S-CTLA, and the distribution of contrast agent during BOAI into both internal iliac arteries simultaneously was evaluated in nine pairs of internal iliac arteries and one single artery. For S-CTLA, spiral CT data were acquired before and after 0.2 ml/sec intraarterial injection of contrast material. The enhancement of the urinary bladder wall, the gluteal muscles, and the pelvic bones was categorized using a 4-grade scale. The grades were compared in each of the three pelvic components and differences were tested for significance using the Wilcoxon test for paired groups. RESULTS: S-CTLA revealed the distribution of the contrast agent clearly. Gluteal muscles grades were significantly higher than those of the other two assessed components. CONCLUSION: BOAI does not improve the concentration of contrast agent to the bladder wall over neighboring structures, suggesting that the balloon occlusion technique does not achieve its desired goal for chemotherapy targeting.
K Mori; H Yoshioka; K Nakajima; T Irie; S Sugahara; K Nozawa; Y Saida; Y Itai; S Ishikawa; H Hayashi
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  23     ISSN:  0174-1551     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:    2000 May-Jun
Date Detail:
Created Date:  2000-08-02     Completed Date:  2000-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  198-201     Citation Subset:  IM    
Department of Radiology, Tsukuba University Hospital, 2-1-1 Amakubo, Tsukuba-shi, Ibaraki 305-8576, Japan.
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MeSH Terms
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*,  pharmacokinetics*
Balloon Dilatation*
Contrast Media / administration & dosage*
Infusions, Intra-Arterial
Middle Aged
Prospective Studies
Sensitivity and Specificity
Statistics, Nonparametric
Subtraction Technique*
Tomography, X-Ray Computed*
Urinary Bladder Neoplasms / drug therapy*,  radiography*
Reg. No./Substance:
0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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