Document Detail

Subtle glucocorticoid excess in patients with adrenal incidentaloma.
MedLine Citation:
PMID:  1543208     Owner:  NLM     Status:  MEDLINE    
Incidentally discovered adrenal tumors (incidentalomas) are fairly common since the advent of noninvasive methods of imaging the abdomen. Patients with incidentaloma usually undergo screening for overproduction of glucocorticoids by measurement of basal steroid excretion. We describe an asymptomatic patient with an incidentaloma with normal basal steroid excretion whose only manifestation of subtle steroid overproduction was the failure of steroid excretion to be suppressed normally with dexamethasone. It appears tht the more careful the search for subtle evidence of steroid overproduction in patients with incidentaloma, the more common the finding; perhaps up to 50% of patients with incidentaloma have some subtle steroid overproduction. We review the literature on this subject, and evaluate the various possible approaches of how intensively to study steroid dynamics in patients with incidentaloma.
H N Rosen; S L Swartz
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  92     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-08     Completed Date:  1992-04-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  213-6     Citation Subset:  AIM; IM    
Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215.
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MeSH Terms
Adenoma / blood*,  surgery
Adrenal Gland Neoplasms / blood*,  surgery
Glucocorticoids / blood*
Reg. No./Substance:

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