Document Detail

Subtle extrapyramidal signs can predict the development of dementia in elderly individuals.
MedLine Citation:
PMID:  8232926     Owner:  NLM     Status:  MEDLINE    
To assess the significance of mild extrapyramidal signs (EPSs) in aging, we prospectively followed 228 elderly individuals without dementia or major neurologic disease at baseline. Seventy-three (32%) showed mild idiopathic EPSs at baseline assessment and 32 (14%) of these 228 individuals met NINCDS-ADRDA criteria for probable or possible Alzheimer's disease on follow-up. While none of these individuals developed Parkinson's disease, those with more than one EPS at baseline were significantly more likely to become demented during follow-up than were those with one or no EPS, an association not confounded by age, education, or gender. Individuals with more than one EPS and with cognitive impairment (CI) at baseline were at highest risk for dementia. EPSs were also independently associated with incident dementia in the absence of CI at baseline. We conclude that mild EPSs are a significant predictor of dementia in elderly individuals.
M Richards; Y Stern; R Mayeux
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  43     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1993-12-20     Completed Date:  1993-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2184-8     Citation Subset:  AIM; IM    
Gertrude H. Sergievsky Center, New York, N.Y. 10032
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MeSH Terms
Aged, 80 and over
Basal Ganglia Diseases / physiopathology*
Cognition Disorders / psychology
Dementia / diagnosis*,  physiopathology,  psychology
Neuropsychological Tests
Predictive Value of Tests
Prospective Studies
Regression Analysis
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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