| Subtle changes in ADMA and l-arginine concentrations in normal pregnancies are unlikely to account for pregnancy-related increased flow-mediated dilatation. | |
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MedLine Citation:
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PMID: 18093231 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Our objective was to investigate whether serum concentrations of asymmetric dimethylarginine (ADMA) or l-arginine correlate to hyperlipidemia or endothelial function in normal pregnancy compared with the non-pregnant subjects. METHODS AND RESULTS: As a part of population-based, prospective cohort Cardiovascular Risk in Young Finns study conducted in Finland we examined 57 pregnant Finnish women throughout gestation and 62 control women matched for age and smoking. Serum glucose, triglycerides (TG), total cholesterol (TC), low-density cholesterol (LDL-C), high-density cholesterol (HDL-C) and ADMA, symmetric dimethylarginine (SDMA) and l-arginine were determined concomitantly with endothelium-dependent brachial artery flow-mediated dilation (FMD), measured by ultrasound. All serum lipid concentrations were significantly higher in pregnant women than in non-pregnant women (P < 0.001 for each). The mean serum ADMA concentration in pregnant women was significantly lower compared with the non-pregnant controls (0.513 micromol l(-1) +/- 0.0593 versus 0.577 micromol l(-1) +/- 0.0710, P < 0.001). Lowered ADMA concentrations did not correlate statistically to FMD in these healthy pregnant women but FMD was enhanced towards the end of pregnancy. CONCLUSIONS: ADMA and l-arginine concentrations fall in normal pregnancy despite marked hypercholesterolemia. Endothelium-dependent vasodilation is enhanced in normal pregnancy but is not statistically correlated to maternal serum ADMA or l-arginine concentrations. |
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Authors:
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Heli Saarelainen; Pirjo Valtonen; Kari Punnonen; Tomi Laitinen; Olli T Raitakari; Markus Juonala; Nonna Heiskanen; Tiina Lyyra-Laitinen; Jorma S A Viikari; Esko Vanninen; Seppo Heinonen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-18 |
Journal Detail:
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Title: Clinical physiology and functional imaging Volume: 28 ISSN: 1475-0961 ISO Abbreviation: Clin Physiol Funct Imaging Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-11 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137604 Medline TA: Clin Physiol Funct Imaging Country: England |
Other Details:
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Languages: eng Pagination: 120-4 Citation Subset: IM |
Affiliation:
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Department of Ob/Gyn, Kuopio University Hospital, University of Kuopio, Kuopio, Finland. heli.saarelainen@kuh.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arginine / analogs & derivatives*, blood* Blood Flow Velocity / physiology Blood Glucose / analysis Brachial Artery / physiology, ultrasonography* Case-Control Studies Cross-Sectional Studies Endothelium, Vascular / physiology Female Finland Humans Lipids / blood Pregnancy Pregnancy Complications, Cardiovascular / blood, physiopathology Prospective Studies Statistics, Nonparametric Vasodilation / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Lipids; 30344-00-4/N,N'-dimethylarginine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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