Document Detail


Subthreshold facilitation and suppression in primary visual cortex revealed by intrinsic signal imaging.
MedLine Citation:
PMID:  8790423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurons in primary visual cortex (area 17) respond vigorously to oriented stimuli within their receptive fields; however, stimuli presented outside the suprathreshold receptive field can also influence their responses. Here we describe a fundamental feature of the spatial interaction between suprathreshold center and subthreshold surround. By optical imaging of intrinsic signals in area 17 in response to a stimulus border, we show that a given stimulus generates activity primarily in iso-orientation domains, which extend for several millimeters across the cortical surface in a manner consistent with the architecture of long-range horizontal connections in area 17. By mapping the receptive fields of single neurons and imaging responses from the same cortex to stimuli that include or exclude the aggregate suprathreshold receptive field, we show that intrinsic signals strongly reveal the subthreshold surround contribution. Optical imaging and single-unit recording both demonstrate that the relative contrast of center and surround stimuli regulates whether surround interactions are facilitative or suppressive: the same surround stimulus facilitates responses when center contrast is low, but suppresses responses when center contrast is high. Such spatial interactions in area 17 are ideally suited to contribute to phenomena commonly regarded as part of "higher-level" visual processing, such as perceptual "popout" and "filling-in."
Authors:
L J Toth; S C Rao; D S Kim; D Somers; M Sur
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  93     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9869-74     Citation Subset:  IM; S    
Affiliation:
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA. ljtoth@mit.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping
Cats
Female
Image Processing, Computer-Assisted
Neural Inhibition
Neurons / physiology
Photic Stimulation
Sensory Thresholds
Visual Cortex / cytology,  physiology*
Visual Perception / physiology*
Grant Support
ID/Acronym/Agency:
EY07023/EY/NEI NIH HHS
Comments/Corrections

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