Document Detail

Subthalamic stimulation improves levodopa responsive symptoms in a case of progressive supranuclear palsy.
MedLine Citation:
PMID:  17825599     Owner:  NLM     Status:  MEDLINE    
A case is described of a patient with levodopa responsive parkinsonism, dyskinesia, and off periods who underwent bilateral deep brain stimulation of the subthalamic nuclei (DBS-STN) with good result. As the disease progressed, the patient fit diagnostic criteria for progressive supranuclear palsy parkinsonism (PSP-P). Benefit of DBS for the parkinsonian phenomena is still apparent 4 years later. That DBS-STN provided targeted symptom relief in this unusual patient suggests that the parkinsonism of PSP-P and that of Parkinson's disease (PD) may share a common pathophysiologic mechanism. The presence of dystonic features in this illness raises the possibility that the globus pallidus might also have been an effective target.
Kenneth J Bergmann; Vicky L Salak
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Publication Detail:
Type:  Journal Article     Date:  2007-09-06
Journal Detail:
Title:  Parkinsonism & related disorders     Volume:  14     ISSN:  1353-8020     ISO Abbreviation:  Parkinsonism Relat. Disord.     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-02     Completed Date:  2008-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513583     Medline TA:  Parkinsonism Relat Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  348-52     Citation Subset:  IM    
Murray Center for Research on Parkinson's Disease and Related Disorders, Movement Disorders Program, Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.
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MeSH Terms
Deep Brain Stimulation / methods*
Dopamine Agents / therapeutic use
Levodopa / therapeutic use
Longitudinal Studies
Magnetic Resonance Imaging
Middle Aged
Neuropsychological Tests
Retrospective Studies
Subthalamic Nucleus / physiology*
Supranuclear Palsy, Progressive / physiopathology,  therapy*
Time Factors
Reg. No./Substance:
0/Dopamine Agents; 0/Levodopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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