| Subthalamic stimulation improves levodopa responsive symptoms in a case of progressive supranuclear palsy. | |
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MedLine Citation:
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PMID: 17825599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case is described of a patient with levodopa responsive parkinsonism, dyskinesia, and off periods who underwent bilateral deep brain stimulation of the subthalamic nuclei (DBS-STN) with good result. As the disease progressed, the patient fit diagnostic criteria for progressive supranuclear palsy parkinsonism (PSP-P). Benefit of DBS for the parkinsonian phenomena is still apparent 4 years later. That DBS-STN provided targeted symptom relief in this unusual patient suggests that the parkinsonism of PSP-P and that of Parkinson's disease (PD) may share a common pathophysiologic mechanism. The presence of dystonic features in this illness raises the possibility that the globus pallidus might also have been an effective target. |
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Authors:
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Kenneth J Bergmann; Vicky L Salak |
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Publication Detail:
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Type: Journal Article Date: 2007-09-06 |
Journal Detail:
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Title: Parkinsonism & related disorders Volume: 14 ISSN: 1353-8020 ISO Abbreviation: Parkinsonism Relat. Disord. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-06-02 Completed Date: 2008-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513583 Medline TA: Parkinsonism Relat Disord Country: England |
Other Details:
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Languages: eng Pagination: 348-52 Citation Subset: IM |
Affiliation:
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Murray Center for Research on Parkinson's Disease and Related Disorders, Movement Disorders Program, Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA. Bergmann@musc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Deep Brain Stimulation
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methods* Dopamine Agents / therapeutic use Female Humans Levodopa / therapeutic use Longitudinal Studies Magnetic Resonance Imaging Middle Aged Neuropsychological Tests Retrospective Studies Subthalamic Nucleus / physiology* Supranuclear Palsy, Progressive / physiopathology, therapy* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agents; 0/Levodopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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