| Substrates of auditory frequency integration in a nucleus of the lateral lemniscus. | |
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MedLine Citation:
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PMID: 20451586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the intermediate nucleus of the lateral lemniscus (INLL), some neurons display a form of spectral integration in which excitatory responses to sounds at their best frequency are inhibited by sounds within a frequency band at least one octave lower. Previous work showed that this response property depends on low-frequency-tuned glycinergic input. To identify all sources of inputs to these INLL neurons, and in particular the low-frequency glycinergic input, we combined retrograde tracing with immunohistochemistry for the neurotransmitter glycine. We deposited a retrograde tracer at recording sites displaying either high best frequencies (>75 kHz) in conjunction with combination-sensitive inhibition, or at sites displaying low best frequencies (23-30 kHz). Most retrogradely labeled cells were located in the ipsilateral medial nucleus of the trapezoid body (MNTB) and contralateral anteroventral cochlear nucleus. Consistent labeling, but in fewer numbers, was observed in the ipsilateral lateral nucleus of the trapezoid body (LNTB), contralateral posteroventral cochlear nucleus, and a few other brainstem nuclei. When tracer deposits were combined with glycine immunohistochemistry, most double-labeled cells were observed in the ipsilateral MNTB (84%), with fewer in LNTB (13%). After tracer deposits at combination-sensitive recording sites, a striking result was that MNTB labeling occurred in both medial and lateral regions. This labeling appeared to overlap the MNTB labeling that resulted from tracer deposits in low-frequency recording sites of INLL. These findings suggest that MNTB is the most likely source of low-frequency glycinergic input to INLL neurons with high best frequencies and combination-sensitive inhibition. This work establishes an anatomical basis for frequency integration in the auditory brainstem. |
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Authors:
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A Yavuzoglu; B R Schofield; J J Wenstrup |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-05-06 |
Journal Detail:
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Title: Neuroscience Volume: 169 ISSN: 1873-7544 ISO Abbreviation: Neuroscience Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-14 Completed Date: 2010-11-23 Revised Date: 2012-10-18 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 906-19 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 IBRO. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Anatomy and Neurobiology, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio 44272, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Action Potentials Animals Auditory Pathways / physiology* Brain Stem / anatomy & histology, physiology* Chiroptera / physiology* Glycine / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 DC000937/DC/NIDCD NIH HHS; R01 DC000937-19/DC/NIDCD NIH HHS; R01 DC00937/DC/NIDCD NIH HHS; R01 DC04391/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-40-6/Glycine |
| Comments/Corrections | |
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