Document Detail


Substrate specificity of lecithin:cholesterol acyltransferase. Esterification of desmosterol, b-sitosterol, and cholecalciferol in human plasma.
MedLine Citation:
PMID:  174187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Desmosterol and beta-sitosterol were esterified when incubated with normal human plasma. The initial rate of demosterol esterification was 1.7 times faster, and that of beta-sitosterol 0.4 times slower, than the esterification rate of cholesterol. These ratios were found to be almost the same when plasma from different normal individuals was tested. Plasma from a patient with familial lecithin:cholesterol acyltransferase deficiency did not esterify any of the sterols. The esterification of desmosterol and beta-sitosterol was considerably slower in normal plasma in which in vitro cholesterol esterification previously had taken place. The different esterification rates could not be explained by a different affinity of the plasma lipoproteins for the sterols tested. Cholecalciferol added to normal plasma did not become esterified.
Authors:
G Nordby; K R Norum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  35     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  677-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acyltransferases / blood*
Adult
Cholecalciferol / blood*
Cholesterol / blood
Desmosterol / blood*
Esterification
Female
Humans
Lecithin Acyltransferase Deficiency
Lipids / blood
Lipoproteins / blood
Male
Phosphatidylcholine-Sterol O-Acyltransferase / blood*
Sitosterols / blood*
Time Factors
Chemical
Reg. No./Substance:
0/Lipids; 0/Lipoproteins; 0/Sitosterols; 313-04-2/Desmosterol; 57-88-5/Cholesterol; 67-97-0/Cholecalciferol; EC 2.3.-/Acyltransferases; EC 2.3.1.43/Phosphatidylcholine-Sterol O-Acyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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