Document Detail

Substrate-specific regulation of ubiquitination by the anaphase-promoting complex.
MedLine Citation:
PMID:  21191176     Owner:  NLM     Status:  MEDLINE    
By orchestrating the sequential degradation of a large number of cell cycle regulators, the ubiquitin ligase anaphase-promoting complex (APC/C) is essential for proliferation in all eukaryotes. The correct timing of APC/C-dependent substrate degradation, a critical feature of progression through mitosis, was long known to be controlled by mechanisms targeting the core APC/C-machinery. Recent experiments, however, have revealed an important contribution of substrate-specific regulation of the APC/C to achieve accurate cell division. In this perspective, we describe different mechanisms of substrate-specific APC/C-regulation and discuss their importance for cell division.
Ling Song; Michael Rape
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-01-01
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  10     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-20     Completed Date:  2011-11-15     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52-6     Citation Subset:  IM    
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
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MeSH Terms
Cell Division / physiology
Protein Binding / physiology
Substrate Specificity / physiology
Ubiquitin-Protein Ligase Complexes / physiology*
Ubiquitination / physiology*
Reg. No./Substance:
EC Ligase Complexes; EC complex

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