Document Detail


Substrate repletion in rat myocardium, liver, and skeletal muscles after exercise.
MedLine Citation:
PMID:  7470995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carbohydrate and lipid substrates were measured in rats during recovery following exercise or a 24-h fast and compared with values from time-matched control (rested, fed) rats. After exercise muscle glycogen recovered at the expense of liver glycogen repletion. Myocardial glycogen supercompensated whereas soleus, red vastus lateralis (RVL) and white vastus lateralis glycogen merely returned to control levels. A similar recovery pattern occurred after fasting with refeeding promoting glycogen synthesis in the liver, skeletal muscles, and even in the myocardium, where glycogen had already been elevated by the fast. Both soleus and RVL muscles, along with the myocardium, exhibited glycogen supercompensation. Both exercise and fasting increased plasma free fatty acid (FFA) levels which favor myocardial glycogen synthesis. Unchanged tissue triglycerides and relatively stable blood glucose levels suggest that these are unlikely influences on glycogen recovery. It is concluded that exercise per se is unlikely to induce glycogen supercompensation in skeletal muscles though myocardial glycogen supercompensation readily occurs, that food restriction prior to exercise quantitatively affects substrate recovery though its impact could go unnoticed because of the qualitative similarities between substrate recovery following exercise or fasting, and that FFA is the only major energy substrate concurrently changing with glycogen after exercise or fasting which could facilitate glycogen synthesis.
Authors:
J L Poland; C Trowbridge; J W Poland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  58     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1981-05-21     Completed Date:  1981-05-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1229-33     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Fatty Acids, Nonesterified / metabolism
Glucose / metabolism
Glycogen / metabolism
Liver / metabolism*
Male
Muscles / metabolism*
Myocardium / metabolism*
Physical Exertion*
Rats
Time Factors
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Triglycerides; 50-99-7/Glucose; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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