| Substrate preference of metalloproteinases secreted by ts-110 Moloney murine sarcoma virus-transformed normal rat kidney cells. | |
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MedLine Citation:
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PMID: 1449476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, the two forms of affinity-purified transformation-associated proteins (TAPs) (68 and 64 kD) were shown to have different substrate preferences. For the 68-kD TAP, the order of substrate preference was collagen types I, III, and V; fibronectin; gelatin; and collagen IV. For the 64-kD TAP, the order of substrate preference was collagen I, III, and V and gelatin. The 64-kD TAP did not cleave collagen IV and fibronectin. We also found a 71-kD metalloproteinase in the concentrated purified TAPs that reacted only weakly with a TAP monoclonal antibody and showed this substrate preference: collagen I, III, and V; gelatin; and collagen IV. Whether this 71-kD TAP is a new member of the rat metalloproteinase family will be investigated. |
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Authors:
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H Z Zhang; M Scanlon; J L Murray; J C Chan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 189 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1992-12-30 Completed Date: 1992-12-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 21-6 Citation Subset: IM |
Affiliation:
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Department of Tumor Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies Antibodies, Monoclonal Blotting, Western Cell Line, Transformed Cell Transformation, Neoplastic* Collagen / metabolism Electrophoresis, Polyacrylamide Gel Kidney Metalloendopeptidases* / isolation & purification, metabolism* Molecular Weight Moloney murine sarcoma virus / genetics* Rats Substrate Specificity |
| Grant Support | |
ID/Acronym/Agency:
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CM 97910/CM/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antibodies, Monoclonal; 9007-34-5/Collagen; EC 3.4.24.-/Metalloendopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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