Document Detail

Substrate metabolism in the isolated perfused dog kidney.
MedLine Citation:
PMID:  972006     Owner:  NLM     Status:  MEDLINE    
The relationships between substrate utilization and renal work were investigated in an isolated, perfused dog kidney preparation: substrate utilization included free-fatty acid (FFA), glucose, and oxygen, whereas work was assessed by measuring TNa+. The magnitude of TNa+ was varied by altering glomerular filtration rate as a consequence of changing renal blood flow. As the rate of renal blood flow was reduced, both Qo2, and QFFA decreased while Qglucose increased. The reduction in QFFA and Qo2 paralleled the decrease in TNa+. An inverse relationship was noted between QFFA and Qglucose in all experiments. The results suggest that FFA and perhaps glucose may serve as a significant substrate for providing energy for TNA+ in the kidney. Further, since QFFA and Qglucose are inversely related to each other, glucose may substitute for FFA as an energy source at times when QFFA is reduced.
M Tark; H M Randall; T L Hoffer
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative urology     Volume:  14     ISSN:  0021-0005     ISO Abbreviation:  Invest Urol     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-12-03     Completed Date:  1976-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374747     Medline TA:  Invest Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  132-6     Citation Subset:  IM    
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MeSH Terms
Energy Metabolism
Fatty Acids, Nonesterified / metabolism
Glomerular Filtration Rate
Glucose / metabolism
Kidney / blood supply,  metabolism*
Oxygen Consumption
Regional Blood Flow
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 50-99-7/Glucose

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