Document Detail


Substrate metabolism as a determinant for postischemic functional recovery of the heart.
MedLine Citation:
PMID:  9293950     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mammalian myocardium meets its high energy needs through the oxidation of a variety of substrates, chiefly fatty acids. This review examines the hypothesis that efficient energy transfer in the heart occurs through a series of moiety-conserved cycles, which makes the heart an obligatory "omnivore." Ischemia results in a transformation of efficient metabolic cycles to less-efficient linear pathways. Substrate metabolism during reperfusion requires the replenishment of depleted cycles and is a major determinant for the return of contractile function. Although there is growing recognition of the concept that regulation of substrate flux through metabolic pathways is shared by several of the pathway enzymes it is apparent that glucose oxidation and glycogen resynthesis promote the return of normal contractile function in the postischemic heart. This concept is supported by clinical observations on the beneficial effects of a solution containing glucose, insulin, and potassium (GIK) for treatment of refractory left ventricular contractile failure after hypothermic ischemic arrest during cardiac surgery.
Authors:
H Taegtmeyer; G W Goodwin; T Doenst; O H Frazier
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  80     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-25     Completed Date:  1997-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3A-10A     Citation Subset:  AIM; IM    
Affiliation:
University of Texas-Houston Medical School, Department of Medicine, Texas Heart Institute, 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Glucose / metabolism
Glycogen / metabolism
Humans
Insulin / metabolism
Myocardial Ischemia / metabolism*
Myocardium / metabolism*
Oxidation-Reduction
Potassium / metabolism
Grant Support
ID/Acronym/Agency:
R01-HL43133/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
11061-68-0/Insulin; 50-99-7/Glucose; 7440-09-7/Potassium; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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