| Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters. | |
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MedLine Citation:
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PMID: 19113896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A close structural analogue of bryostatin 1, which differs from bryostatin 1 only by the absence of the C(30) carbomethoxy group (on the C(13) enoate of the B-ring), has been prepared by total synthesis. Biological assays reveal a crucial role for substitution in the bryostatin 1 A-ring in conferring those responses which are characteristic of bryostatin 1 and distinct from those observed with PMA. |
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Authors:
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Gary E Keck; Yam B Poudel; Dennie S Welch; Matthew B Kraft; Anh P Truong; Jeffrey C Stephens; Noemi Kedei; Nancy E Lewin; Peter M Blumberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Organic letters Volume: 11 ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-29 Completed Date: 2009-02-26 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 593-6 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Utah, 315 South 1400 East, RM 2020, Salt Lake City, Utah 84112, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
/
chemical synthesis*,
chemistry*,
pharmacology Bryostatins / chemical synthesis, chemistry*, pharmacology Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Molecular Structure Phorbol Esters / chemistry*, pharmacology Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
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GM28961/GM/NIGMS NIH HHS; R01 GM028961-18/GM/NIGMS NIH HHS; R01 GM028961-19/GM/NIGMS NIH HHS; R01 GM028961-20/GM/NIGMS NIH HHS; R01 GM028961-21/GM/NIGMS NIH HHS; R01 GM028961-22/GM/NIGMS NIH HHS; R01 GM028961-23/GM/NIGMS NIH HHS; R01 GM028961-24/GM/NIGMS NIH HHS; R01 GM028961-25A1/GM/NIGMS NIH HHS; R01 GM028961-26/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Bryostatins; 0/Phorbol Esters; 83314-01-6/bryostatin 1 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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