Document Detail


Substitution of oral (18)F-FDG for intravenous (18)F-FDG in PET scanning.
MedLine Citation:
PMID:  17496005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to see whether oral administration of (18)F-FDG could be substituted-without significant loss of information-for intravenous injection of (18)F-FDG in patients with difficult intravenous access of any cause, such as that often seen in cancer patients after many cycles of chemotherapy. METHODS: PET after both oral and intravenous administration of (18)F-FDG was performed on 2 healthy volunteers and 7 patients. An interval of 48 h was maintained between the oral administration and the intravenous administration. All scans were visually analyzed. Semiquantitative analysis of specific areas was done by calculating standardized uptake values (SUVs). Scanning was performed 60 min after intravenous tracer administration and 90 min after oral tracer administration. RESULTS: All lesions seen after intravenous administration were visualized on the oral study as well. SUVs were lower on the oral study than on the intravenous study. CONCLUSION: Oral (18)F-FDG can successfully be substituted for intravenous (18)F-FDG in patients with difficult intravenous access. However, because of the large amount of (18)F-FDG retained in the gut, careful interpretation will be required when disease of the gastrointestinal tract is being evaluated.
Authors:
Narendra Nair; Archi Agrawal; Rajnath Jaiswar
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article     Date:  2007-05-11
Journal Detail:
Title:  Journal of nuclear medicine technology     Volume:  35     ISSN:  0091-4916     ISO Abbreviation:  J Nucl Med Technol     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-31     Completed Date:  2007-08-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0430303     Medline TA:  J Nucl Med Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  100-4     Citation Subset:  IM    
Affiliation:
Radiation Medicine Centre, Tata Memorial Hospital Annexe, Parel, Mumbai, India.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adolescent
Female
Fluorodeoxyglucose F18 / administration & dosage*,  diagnostic use*
Humans
Image Enhancement / methods*
Injections, Intravenous
Male
Middle Aged
Neoplasms / radionuclide imaging*
Positron-Emission Tomography / methods*
Radiopharmaceuticals / administration & dosage,  diagnostic use
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18

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