Document Detail


Substitution of aspartic acid at position 57 of the DQbeta1 affects relapse of autoimmune pancreatitis.
MedLine Citation:
PMID:  18155707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND & AIMS: Although autoimmune pancreatitis (AIP) responds well to corticosteroid therapy, relapse during maintenance corticosteroid therapy or after the withdrawal of corticosteroid treatment is not uncommon. To date, the factors related to relapse of AIP have not been fully explored. METHODS: To determine the clinical and genetic predictors relating to the relapse of AIP, we evaluated clinical factors, HLA polymorphisms, and the amino acid sequences in 40 patients with AIP. RESULTS: At a median follow-up period of 40 months (range, 12-67 months), relapse developed in 13 of 40 patients with AIP (33%), in whom complete remission was achieved with oral corticosteroid therapy. Among demographics, clinical characteristics in the initial diagnosis of AIP, we could not find any clinical predictor for relapse of AIP; however, in amino acid sequence analysis for relapse of AIP, the substitution of aspartic acid to nonaspartic acid at residue 57 of DQbeta1 showed a significant association with relapse of AIP (nonrelapse group, 29.6%; relapse group, 100%; P = .00003; odds ratio, 3.38; 95% confidence interval, 1.9-6.0). There was a significant difference in the timing of relapse of AIP, according to density of the nonaspartic acid residue at DQbeta1 57 (nonaspartic acid homozygosity: mean +/- SD, 6.7 +/- 4.2 months; nonaspartic acid heterozygosity: mean +/- SD, 33 +/- 11 months; P < .001). CONCLUSIONS: Substitution of aspartic acid to nonaspartic acid at DQbeta1 57 appears to represent a key genetic factor for relapse of AIP (ClinicalTrials.gov number, NCT00444444).
Authors:
Do Hyun Park; Myung-Hwan Kim; Heung Bum Oh; Oh-Joong Kwon; Young-Jin Choi; Sang-Soo Lee; Tae Yoon Lee; Dong-Wan Seo; Sung-Koo Lee
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Publication Detail:
Type:  Journal Article     Date:  2007-11-17
Journal Detail:
Title:  Gastroenterology     Volume:  134     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-02-14     Revised Date:  2010-10-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  440-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Adult
Aged
Alleles
Amino Acid Sequence
Aspartic Acid / genetics
Autoimmune Diseases / drug therapy,  genetics*
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Genetic Predisposition to Disease
HLA-DQ Antigens / chemistry,  genetics*
Humans
Immunosuppressive Agents / therapeutic use
Longitudinal Studies
Male
Middle Aged
Molecular Sequence Data
Pancreatitis / drug therapy,  genetics*,  immunology*
Polymorphism, Genetic
Predictive Value of Tests
Prednisolone / therapeutic use
Recurrence
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/HLA-DQ Antigens; 0/HLA-DQB1 antigen; 0/Immunosuppressive Agents; 50-24-8/Prednisolone; 56-84-8/Aspartic Acid
Comments/Corrections
Comment In:
Gastroenterology. 2008 Feb;134(2):625-8   [PMID:  18242227 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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