| Substitution of Standard Soybean Oil with Olive Oil-Based Lipid Emulsion in Parenteral Nutrition: Comparison of Vascular, Metabolic, and Inflammatory Effects. | |
| | |
MedLine Citation:
|
PMID: 21832112 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Context: Soybean oil-based lipid emulsions are the only Food and Drug Administration-approved lipid formulation for clinical use in parenteral nutrition (PN). Recently concerns with its use have been raised due to the proinflammatory effects that may lead to increased complications because they are rich in ω-6 polyunsaturated fatty acids. Methods: This was a prospective, randomized, controlled, crossover study comparing the vascular, metabolic, immune, and inflammatory effects of 24-h infusion of PN containing soybean oil-based lipid emulsion (Intralipid), olive oil-based (ClinOleic), lipid free, and normal saline in 12 healthy subjects. Results: Soybean oil-PN increased systolic blood pressure compared with olive oil-PN (P < 0.05). Soybean oil PN reduced brachial artery flow-mediated dilatation from baseline (-23% at 4 h and -25% at 24 h, both P < 0.01); in contrast, olive oil PN, lipid free PN, and saline did not change either systolic blood pressure or flow-mediated dilatation. Compared with saline, soybean oil PN, olive oil PN, and lipid free PN similarly increased glucose and insulin concentrations during infusion (P < 0.05). There were no significant changes in plasma free fatty acids, lipid profile, inflammatory and oxidative stress markers, immune function parameters, or sympathetic activity between soybean oil- and olive oil-based lipid emulsions. Conclusion: The 24-h infusion of PN containing soybean oil-based lipid emulsion increased blood pressure and impaired endothelial function compared with PN containing olive oil-based lipid emulsion and lipid-free PN in healthy subjects. These vascular changes may have significant implications in worsening outcome in subjects receiving nutrition support. Randomized controlled trials with relevant clinical outcome measures are needed in patients receiving PN with olive oil-based and soybean oil-based lipid emulsions. |
| | |
Authors:
|
Joselita Siqueira; Dawn Smiley; Christopher Newton; Ngoc-Anh Le; Aidar R Gosmanov; Ronnie Spiegelman; Limin Peng; Samantha J Osteen; Dean P Jones; Arshed A Quyyumi; Thomas R Ziegler; Guillermo E Umpierrez |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-10 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Medicine (J.S., D.S., C.N., N.-A.L., R.S., S.J.O., D.P.J., A.A.Q., T.R.Z., G.E.U.), Atlanta Veterans Affairs Medical Center (N.-A.L.), and Rollins School of Public Health (L.P.), Emory University, Atlanta, Georgia 30303; and University of Tennessee Health Science Center (A.R.G.), Memphis, Tennessee 38163. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metformin and/or Clomiphene Do Not Adversely Affect Liver or Renal Function in Women with Polycystic...
Next Document: C-Reactive Protein in Adolescent Twins: Patterns and Relationship to Adiposity.