| Substituted pyrroles via olefin cross-metathesis. | |
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MedLine Citation:
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PMID: 20712303 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin. |
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Authors:
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Timothy J Donohoe; Nicholas J Race; John F Bower; Cedric K A Callens |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Organic letters Volume: 12 ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-10 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 4094-7 Citation Subset: - |
Affiliation:
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Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK. timothy.donohoe@chem.ox.ac.uk |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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