Document Detail

Substituted pyrroles via olefin cross-metathesis.
MedLine Citation:
PMID:  20712303     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.
Timothy J Donohoe; Nicholas J Race; John F Bower; Cedric K A Callens
Related Documents :
23386323 - Pethidinic acid: corroboration of a doctor's denial of pethidine re-use.
10836063 - Synthesis of l-4,4-difluoroglutamic acid via electrophilic difluorination of a lactam.
7335963 - Biochemical changes in acute respiratory failure.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Organic letters     Volume:  12     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-10     Completed Date:  2010-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4094-7     Citation Subset:  -    
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Synthesis of sulfuric macrocycles and a rotaxane through thiol-yne click and dithiol coupling reacti...
Next Document:  Total synthesis and anticancer activities of (-)- and (+)-thespesone.