Document Detail


Substantial systolic improvement and reverse cardiac remodeling in elderly-onset idiopathic dilated cardiomyopathy > or = 65 years of age.
MedLine Citation:
PMID:  18678207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Significant systolic improvement and reverse remodeling in dilated cardiomyopathy (DCM) are well known, however they have been rarely described among elderly subjects. The authors retrospectively reviewed 86 patients with a diagnosis of DCM seen at a clinic during April-November 2005. The authors found 18 patients with elderly-onset idiopathic DCM (age of onset > or = 65 years, mean age 71.8 +/- 6.2 years), who had substantial improvement in left ventricular ejection fraction (LVEF) > or = 20 units (%). During a mean follow-up of 8.6 +/- 5.5 years, mean LVEF and left ventricular end-diastolic diameter improved from 30.6 +/- 7.9% to 58.3 +/- 6.5% (p < 0.0001) and 57.5 +/- 7.0 mm to 44.6 +/- 5.5 mm (p < 0.0001), respectively Fifteen of the 18 patients (83%) had a history of hypertension. Systolic blood pressure at the initial referral clinic correlated with improved contractility (p = 0.0275, r = 0.52). The eighteen patients found in our small patient population suggest that substantial systolic improvement and reverse remodeling is seen in elderly patients with idiopathic DCM.
Authors:
Katsufumi Nishida; Hiroki Ito; Osamu Fukuyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hawaii medical journal     Volume:  67     ISSN:  0017-8594     ISO Abbreviation:  Hawaii Med J     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-08-05     Completed Date:  2008-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984209R     Medline TA:  Hawaii Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  156-9     Citation Subset:  IM    
Affiliation:
University of Hawai'i John A Burns School of Medicine, Department of Internal Medicine, Honolulu, HI 96813, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use
Aged
Angiotensin II Type 1 Receptor Blockers / therapeutic use
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Anticoagulants / therapeutic use
Cardiomyopathy, Dilated / physiopathology,  prevention & control*,  ultrasonography
Cardiotonic Agents / therapeutic use
Digoxin / therapeutic use
Female
Humans
Male
Retrospective Studies
Stroke Volume / physiology*
Systole / physiology
Ventricular Function, Left / physiology
Ventricular Remodeling*
Warfarin / therapeutic use
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Anticoagulants; 0/Cardiotonic Agents; 20830-75-5/Digoxin; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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