| Substantial systolic improvement and reverse cardiac remodeling in elderly-onset idiopathic dilated cardiomyopathy > or = 65 years of age. | |
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MedLine Citation:
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PMID: 18678207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Significant systolic improvement and reverse remodeling in dilated cardiomyopathy (DCM) are well known, however they have been rarely described among elderly subjects. The authors retrospectively reviewed 86 patients with a diagnosis of DCM seen at a clinic during April-November 2005. The authors found 18 patients with elderly-onset idiopathic DCM (age of onset > or = 65 years, mean age 71.8 +/- 6.2 years), who had substantial improvement in left ventricular ejection fraction (LVEF) > or = 20 units (%). During a mean follow-up of 8.6 +/- 5.5 years, mean LVEF and left ventricular end-diastolic diameter improved from 30.6 +/- 7.9% to 58.3 +/- 6.5% (p < 0.0001) and 57.5 +/- 7.0 mm to 44.6 +/- 5.5 mm (p < 0.0001), respectively Fifteen of the 18 patients (83%) had a history of hypertension. Systolic blood pressure at the initial referral clinic correlated with improved contractility (p = 0.0275, r = 0.52). The eighteen patients found in our small patient population suggest that substantial systolic improvement and reverse remodeling is seen in elderly patients with idiopathic DCM. |
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Authors:
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Katsufumi Nishida; Hiroki Ito; Osamu Fukuyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hawaii medical journal Volume: 67 ISSN: 0017-8594 ISO Abbreviation: Hawaii Med J Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-08-05 Completed Date: 2008-09-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984209R Medline TA: Hawaii Med J Country: United States |
Other Details:
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Languages: eng Pagination: 156-9 Citation Subset: IM |
Affiliation:
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University of Hawai'i John A Burns School of Medicine, Department of Internal Medicine, Honolulu, HI 96813, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Aged Angiotensin II Type 1 Receptor Blockers / therapeutic use Angiotensin-Converting Enzyme Inhibitors / therapeutic use Anticoagulants / therapeutic use Cardiomyopathy, Dilated / physiopathology, prevention & control*, ultrasonography Cardiotonic Agents / therapeutic use Digoxin / therapeutic use Female Humans Male Retrospective Studies Stroke Volume / physiology* Systole / physiology Ventricular Function, Left / physiology Ventricular Remodeling* Warfarin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Anticoagulants; 0/Cardiotonic Agents; 20830-75-5/Digoxin; 81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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