| Substantia nigra output to prefrontal cortex via thalamus in monkeys. I. Electrophysiological identification of thalamic relay neurons. | |
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MedLine Citation:
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PMID: 19692504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A few studies have been performed in primate basal ganglia-thalamo-prefrontal pathways. Nevertheless, their electrophysiological properties and anatomical arrangements remain obscure. This study examined them in nigro-thalamo-cortical pathways from the substantia nigra pars reticulata (SNr) to the frontal cortex (FRC) via the mediodorsal (MD) and ventral anterior (VA) thalamus in monkeys. First, single thalamocortical neurons with SNr input were identified by antidromic responses to FRC stimulation and by inhibitory orthodromic responses with short latencies (<5 ms) to SNr stimulation. Second, single nigrothalamic neurons were found by antidromic responses to stimulation of the portions of the MD and VA where the thalamocortical neurons were recorded. The inhibitory orthodromic responses in the thalamocortical neurons were considered to be monosynaptically induced by nigral stimulation because the latency distribution of the orthodromic responses in the thalamocortical neurons was similar to that of the antidromic responses in the nigrothalamic neurons. Almost all relay neurons in the rostrolateral MD received inhibitory afferents from the caudolateral SNr and projected to the prefrontal area ventral to the principal sulcus, which constituted the densest nigro-thalamo-cortical projections. Meanwhile, neurons in the VA received inhibitory signals from the whole rostrocaudal extent of the SNr and projected to wide regions of the FRC; neurons in its pars magnocellularis mostly projected to different prefrontal areas, while those in its pars parvocellularis projected to motor areas. This report substantiated the topography of thalamocortical neurons monosynaptically receiving inhibitory SNr input and projecting to the FRC in the primate MD and VA at the single-neuron level. |
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Authors:
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Ikuo Tanibuchi; Hiroyuki Kitano; Kohnosuke Jinnai |
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Publication Detail:
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Type: Journal Article Date: 2009-08-19 |
Journal Detail:
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Title: Journal of neurophysiology Volume: 102 ISSN: 1522-1598 ISO Abbreviation: J. Neurophysiol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-05 Completed Date: 2010-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 2933-45 Citation Subset: IM |
Affiliation:
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Department of Physiology, Shiga University of Medical Science, Seta Tsukinowa-cho, Ohtsu, Shiga 520-2192, Japan. buchi@belle.shiga-med.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Animals Biophysics Brain Mapping* Electric Stimulation / methods Interneurons / classification, physiology* Macaca fascicularis Male Prefrontal Cortex / physiology* Reaction Time / physiology Substantia Nigra / physiology* Thalamus / cytology*, physiology |
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