| Substantia nigra output to prefrontal cortex via thalamus in monkeys. II. Activity of thalamic relay neurons in delayed conditional go/no-go discrimination task. | |
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MedLine Citation:
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PMID: 19692503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present report investigated the involvement of primate nigro-thalamo-cortical projections in discrimination of visual signals with behavioral meaning. We tested the extracellular unit activity of mediodorsal (MD) and ventral anterior (VA) thalamic neurons monosynaptically receiving inhibitory input from the substantia nigra pars reticulata (SNr) and projecting to the frontal cortex in Japanese monkeys performing a delayed conditional go/no-go discrimination task. In the task two colored stimuli (S1, S2) intervened by delay period required the monkeys lifting a lever (go) or not (no-go); the same and different colored pairs of S1 and S2 meant go and no-go signals, respectively. Prominent task-relevant responses were sustained activity with color preference to S1 during delay period and S2-related activity with different firing rates between go and no-go trials. In particular, a high proportion of such go/no-go differential S2-related activity was found in thalamic relay neurons, receiving input from the caudolateral SNr and projecting to the prefrontal area (PSv) ventral to the principal sulcus, in the rostrolateral MD. The findings suggest that the caudolateral SNr-rostrolateral MD-PSv pathways may be possible conduits of signals coding the behavioral meaning of the visual stimuli and thus may be responsible for generating similar neuronal activity in the PSv. |
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Authors:
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Ikuo Tanibuchi; Hiroyuki Kitano; Kohnosuke Jinnai |
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Publication Detail:
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Type: Journal Article Date: 2009-08-19 |
Journal Detail:
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Title: Journal of neurophysiology Volume: 102 ISSN: 1522-1598 ISO Abbreviation: J. Neurophysiol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-05 Completed Date: 2010-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 2946-54 Citation Subset: IM |
Affiliation:
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Department of Physiology, Shiga University of Medical Science, Seta Tsukinowa-cho, Ohtsu, Shiga 520-2192, Japan. buchi@belle.shiga-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Animals Behavior, Animal Brain Mapping Choice Behavior / physiology* Color Perception / physiology Discrimination (Psychology) / physiology* Interneurons / physiology* Macaca fascicularis Male Neuropsychological Tests Photic Stimulation / methods Prefrontal Cortex / physiology* Reaction Time / physiology Substantia Nigra / physiology* Thalamus / cytology* Visual Pathways / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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