| Substance use of pregnant women and early neonatal morbidity: where to focus intervention? | |
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MedLine Citation:
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PMID: 20524381 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Few studies, and none in Canada, have examined the relation between maternal smoking, alcohol consumption and drug dependence during pregnancy and early neonatal morbidity. METHODS: We analyzed records of singleton live births in Alberta, Canada. Markers of neonatal morbidity were Apgar scores (< 7 at 5 minutes postpartum) and resuscitation measures (2001-2005, N = 191,686), and neonatal intensive care unit (NICU) admissions (2002-2005, N = 154,924). Logistic regression was used to estimate odds ratios (ORs) for self-reported substance use and maternal health before conception, adjusting for maternal age, parity, year and fetal gender. Univariate ORs and population-attributable fractions were computed with and without correction for under-reporting of substance use. RESULTS: Maternal smoking during pregnancy was the most prevalent risk factor, affecting 20% of mothers by self-report, with the figure being possibly twice as high once corrected for under-reporting. Smoking (ORs 1.2), alcohol consumption (ORs 1.2-1.5) and drug dependence (ORs 1.7-2) by the mother during pregnancy were associated with increased risk for each of the markers of early neonatal morbidity (p < 0.05, after correcting for covariates). Eliminating the most common among these risk factors, maternal smoking, would prevent 10-15% of each of the three neonatal morbidity markers. Other recorded factors related to mother's pre-conception health, despite some strong associations, were responsible for only a small proportion of cases. DISCUSSION: We conclude that in preventing early neonatal morbidity among singleton births in Alberta, control of maternal smoking, the most common of the potentially modifiable risk factors, remains an important goal. |
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Authors:
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Igor Burstyn; Nitin Kapur; Nicola M Cherry |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of public health. Revue canadienne de santé publique Volume: 101 ISSN: 0008-4263 ISO Abbreviation: Can J Public Health Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-06-07 Completed Date: 2010-07-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372714 Medline TA: Can J Public Health Country: Canada |
Other Details:
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Languages: eng Pagination: 149-53 Citation Subset: IM |
Affiliation:
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Community and Occupational Medicine Program, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB. Igor.Burstyn@drexel.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alberta
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epidemiology Apgar Score Female Humans Infant, Newborn Infant, Newborn, Diseases / epidemiology*, prevention & control Male Maternal-Fetal Exchange / drug effects Pregnancy Pregnancy Complications / chemically induced, epidemiology*, prevention & control Substance-Related Disorders / epidemiology*, prevention & control |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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