| Substance P in tumors: pheochromocytoma and carcinoid. | |
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MedLine Citation:
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PMID: 6178094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunoreactive substance P (I-SP) was measured in two pheochromocytomas and a carcinoid of the caecum. The pheochromocytomas contained 1,5 and 50 pmol/g I-SP respectively. An HPLC analysis I-SP and catecholamines were enriched in the chromaffin granule fraction. The carcinoid contained 2900 pmol/g I-SP. About 40% of the immunoreactivity behaved like substance P on gel filtration, HPLC and in bioassays (fall in rabbit blood pressure and contraction of the guinea-pig ileum which was abolished by specific tachyphylaxis to substance P). These results indicate that authentic substance P is present in carcinoids and pheochromocytomas and that in the latter it is most likely stored in chromaffin granules. |
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Authors:
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R Gamse; A Saria; A Bucsics; F Lembeck |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Peptides Volume: 2 Suppl 2 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1981 |
Date Detail:
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Created Date: 1982-08-14 Completed Date: 1982-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 275-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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metabolism* Animals Biological Assay Blood Pressure / drug effects Carcinoid Tumor / metabolism* Catecholamines / metabolism Cecal Neoplasms / metabolism Chromaffin Granules / metabolism Chromatography, High Pressure Liquid Female Guinea Pigs Humans Male Muscle Contraction / drug effects Pheochromocytoma / metabolism* Rabbits Rats Somatostatin / metabolism Substance P / metabolism*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 33507-63-0/Substance P; 51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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