Document Detail

Substance P in tumors: pheochromocytoma and carcinoid.
MedLine Citation:
PMID:  6178094     Owner:  NLM     Status:  MEDLINE    
Immunoreactive substance P (I-SP) was measured in two pheochromocytomas and a carcinoid of the caecum. The pheochromocytomas contained 1,5 and 50 pmol/g I-SP respectively. An HPLC analysis I-SP and catecholamines were enriched in the chromaffin granule fraction. The carcinoid contained 2900 pmol/g I-SP. About 40% of the immunoreactivity behaved like substance P on gel filtration, HPLC and in bioassays (fall in rabbit blood pressure and contraction of the guinea-pig ileum which was abolished by specific tachyphylaxis to substance P). These results indicate that authentic substance P is present in carcinoids and pheochromocytomas and that in the latter it is most likely stored in chromaffin granules.
R Gamse; A Saria; A Bucsics; F Lembeck
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  2 Suppl 2     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1981  
Date Detail:
Created Date:  1982-08-14     Completed Date:  1982-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  275-80     Citation Subset:  IM    
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MeSH Terms
Adrenal Gland Neoplasms / metabolism*
Biological Assay
Blood Pressure / drug effects
Carcinoid Tumor / metabolism*
Catecholamines / metabolism
Cecal Neoplasms / metabolism
Chromaffin Granules / metabolism
Chromatography, High Pressure Liquid
Guinea Pigs
Muscle Contraction / drug effects
Pheochromocytoma / metabolism*
Somatostatin / metabolism
Substance P / metabolism*,  pharmacology
Reg. No./Substance:
0/Catecholamines; 33507-63-0/Substance P; 51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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