Document Detail

Substance P in the serum of patients with rheumatoid arthritis.
MedLine Citation:
PMID:  9051855     Owner:  NLM     Status:  MEDLINE    
Serum substance P was assayed in rheumatoid arthritis patients and healthy controls to evaluate whether neurogenic inflammation with substance P release is significant in rheumatoid arthritis. A very sensitive competitive immunoenzymetric assay was used. Mean serum substance P level was significantly higher in rheumatoid arthritis patients than in controls and was not correlated with disease duration, morning stiffness duration, Thompson's articular index, Larsen's radiographic score, or the following laboratory indices of inflammation: erythrocyte sedimentation rate, C-reactive protein, and alpha 1-acid glycoprotein. Neurogenic inflammation with substance P release may contribute significantly to the pathogenesis of rheumatoid arthritis. The absence of correlations between serum substance P and clinical or laboratory indices of inflammation may reflect complex interactions between neurogenic inflammation and other pathogenic mechanisms, which may influence clinical features and laboratory tests in rheumatoid arthritis patients.
M Anichini; S Cesaretti; M Lepori; S Maddali Bongi; M Maresca; M Zoppi
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Revue du rhumatisme (English ed.)     Volume:  64     ISSN:  1169-8446     ISO Abbreviation:  Rev Rhum Engl Ed     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-22     Completed Date:  1997-05-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9313916     Medline TA:  Rev Rhum Engl Ed     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  18-21     Citation Subset:  IM    
Istituto di Clinica Medica Generale e Cardiologia, Universita di Firenze, Italy.
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MeSH Terms
Arthritis, Rheumatoid / blood,  diagnosis*,  physiopathology
Enzyme-Linked Immunosorbent Assay
Middle Aged
Sensitivity and Specificity
Substance P / analysis,  blood*
Reg. No./Substance:
33507-63-0/Substance P

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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