| Substance P content in the cerebrospinal fluid and fluid perfusing cerebral ventricles during elicitation and inhibition of trigemino-hypoglossal reflex in rats. | |
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MedLine Citation:
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PMID: 12031544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to establish whether tooth pulp and periaqueductal central gray (PAG) stimulation affects the release of substance P (SP) into the fluid perfusing the cerebral ventricles in rats. The content of substance P in the cerebrospinal fluid and fluid perfusing cerebral ventricles was determined during incisor pulp stimulation with electrical impulses inducing nociceptive trigemino-hypoglossal reflex and then during inhibition of the reflex by stimulation of PAG. Perfusion of the cerebral ventricles was carried out using artificial cerebrospinal fluid (aCSF). SP-like immunoreactivity (SP-LI) was determined in the samples by radioimmunoassay. Samples were collected in four groups: first group-cerebrospinal fluid (CSF); second group-aCSF perfusates without stimulation; third group-aCSF perfusates during incisor pulp stimulation; fourth group-aCSF perfusates during incisor pulp stimulation and simultaneous inhibition of trigemino-hypoglossal reflex by PAG stimulation. It was shown that incisor pulp stimulation led to the increased release of SP-LI into the fluid perfusing cerebral ventricles. Stimulation of PAG reduced the release of SP-LI into the cerebro-ventricular system to the values obtained before the tooth pulp stimulation. The results indicate that PAG significantly inhibits the release of SP-LI into the rat cerebral ventricular system and may be involved in the inhibition of trigemino-hypoglossal reflex. |
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Authors:
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Maria Zubrzycka; Anna Janecka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 941 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-05-28 Completed Date: 2002-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 29-33 Citation Subset: IM |
Affiliation:
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Department of Experimental and Clinical Physiology, Institute of Physiology and Biochemistry, Medical University, Mazowiecka 6/8, 92-215 Lódz, Poland. pawelska@polbox.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebral Ventricles / physiology Dental Pulp* / innervation, physiopathology Electric Stimulation Hypoglossal Nerve* / physiology Male Periaqueductal Gray* / physiopathology Radioimmunoassay Rats Rats, Long-Evans Reflex* Substance P / cerebrospinal fluid*, secretion Trigeminal Nerve* / physiology |
| Chemical | |
Reg. No./Substance:
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33507-63-0/Substance P |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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