Document Detail

Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model.
MedLine Citation:
PMID:  21540192     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Tenocytes produce substance P (SP), and its receptor (neurokinin-1 receptor (NK-1R)) is expressed throughout the tendon tissue, especially in patients with tendinopathy and tissue changes (tendinosis) including hypercellularity and vascular proliferation. Considering the known effects of SP, one might ask whether SP contributes to these changes.
OBJECTIVES: To test whether development of tendinosis-like changes (hypercellularity and angiogenesis) is accelerated during a 1-week course of exercise with local administration of SP in an established Achilles tendinopathy model.
METHODS: Rabbits were subjected to a protocol of Achilles tendon overuse for 1 week, in conjunction with SP injections in the paratenon. Exercised control animals received NaCl injections or no injections, and unexercised, uninjected controls were also used. Tenocyte number and vascular density, as well as paratendinous inflammation, were evaluated. Immunohistochemistry and in situ hybridisation to detect NK-1R were conducted. Results There was a significant increase in tenocyte number in the SP-injected and NaCl-injected groups compared with both unexercised and exercised, uninjected controls. Tendon blood vessels increased in number in the SP-injected group compared with unexercised controls, a finding not seen in NaCl-injected controls or in uninjected, exercised animals. Paratendinous inflammation was more pronounced in the SP-injected group than in the NaCl controls. NK-1R was detected in blood vessel walls, nerves, inflammatory cells and tenocytes.
CONCLUSIONS: SP accelerated the development of tendinosis-like changes in the rabbit Achilles tendon, which supports theories of a potential role of SP in tendinosis development; a fact of clinical interest since SP effects can be effectively blocked. The angiogenic response to SP injections seems related to paratendinitis.
Gustav Andersson; Ludvig J Backman; Alexander Scott; Ronny Lorentzon; Sture Forsgren; Patrik Danielson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-02
Journal Detail:
Title:  British journal of sports medicine     Volume:  45     ISSN:  1473-0480     ISO Abbreviation:  Br J Sports Med     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-19     Completed Date:  2012-01-24     Revised Date:  2013-04-23    
Medline Journal Info:
Nlm Unique ID:  0432520     Medline TA:  Br J Sports Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1017-22     Citation Subset:  IM    
Department of Integrative Medical Biology, Anatomy Section, Umeå University, Sweden.
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MeSH Terms
Achilles Tendon / blood supply*
Administration, Cutaneous
Cell Proliferation
Cumulative Trauma Disorders / pathology*
Neovascularization, Pathologic / chemically induced
Neurotransmitter Agents / administration & dosage,  adverse effects*
Physical Conditioning, Animal / adverse effects*
Random Allocation
Receptors, Neurokinin-1 / metabolism
Substance P / administration & dosage,  adverse effects*
Tendinopathy / chemically induced*,  pathology
Reg. No./Substance:
0/Neurotransmitter Agents; 0/Receptors, Neurokinin-1; 33507-63-0/Substance P
Comment In:
Orthopade. 2013 Mar;42(3):187-9   [PMID:  23493997 ]

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