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A Subset of Interleukin-21(+) Chemokine Receptor CCR9(+) T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity.
MedLine Citation:
PMID:  21511186     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This study describes a CD4(+) T helper (Th) cell subset marked by coexpression of the cytokine interleukin 21 (IL-21) and the gut-homing chemokine receptor CCR9. Although CCR9(+) Th cells were observed in healthy mice and humans, they were enriched in the inflamed pancreas and salivary glands of NOD mice and in the circulation of Sjögren's syndrome patients. CCR9(+) Th cells expressed large amounts of IL-21, inducible T cell costimulator (ICOS), and the transcription factors Bcl6 and Maf, and also supported antibody production from B cells, thereby resembling T follicular B helper (Tfh) cells. However, in contrast to Tfh cells, CCR9(+) Th cells displayed limited expression of CXCR5 and the targets of CCR9(+) Th cells were CD8(+) T cells whose responsiveness to IL-21 was necessary for the development of diabetes. Thus, CCR9(+) Th cells are a subset of IL-21-producing T helper cells that influence regional specification of autoimmune diseases that affect accessory organs of the digestive system.
Authors:
Helen M McGuire; Alexis Vogelzang; Cindy S Ma; William E Hughes; Pablo A Silveira; Stuart G Tangye; Daniel Christ; David Fulcher; Marika Falcone; Cecile King
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunity     Volume:  34     ISSN:  1097-4180     ISO Abbreviation:  Immunity     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432918     Medline TA:  Immunity     Country:  United States    
Other Details:
Languages:  eng     Pagination:  602-15     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia; University of New South Wales School of Biotechnology and Biomolecular Sciences, UNSW, Sydney 2052, Australia.
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