| Subsequent pregnancy outcome after first pregnancy with normotensive early-onset intrauterine growth restriction at <34 weeks of gestation. | |
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MedLine Citation:
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PMID: 20818960 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to evaluate maternal and fetal outcome of the subsequent pregnancy of primiparous women with a history of early-onset intrauterine growth restriction (IUGR), prompting delivery before 34 weeks of gestation, without concomitant maternal hypertensive disease. DESIGN: Retrospective cohort study. SETTING: Tertiary center in the Netherlands. POPULATION: Women with a normotensive first pregnancy complicated by early-onset severe IUGR, prompting delivery before 34 weeks of gestation. METHODS: Reproductive follow-up data were recorded for 22 women with a normotensive first pregnancy complicated by early-onset severe IUGR before 34 weeks, referred to the University Medical Centre Utrecht, the Netherlands, between 1993 and 2005. MAIN OUTCOME MEASURES: Main outcome measures were recurrent IUGR, perinatal mortality, preterm delivery, preeclampsia (PE), pregnancy-induced hypertension, and other major obstetric complications, for example placental abruption. RESULTS: Mean gestational age at delivery was 29.4 weeks for the index pregnancy compared to 36.4 weeks for the next pregnancy. IUGR recurred in six pregnancies (27.3%). Four subsequent pregnancies were complicated by hypertensive disorders. Perinatal mortality was 72.7% in the index pregnancy, compared to 13.6% in the second pregnancy. Overall, 11 women (54.5%) had an uneventful pregnancy. Conclusion: Women with first pregnancy early-onset IUGR, without concomitant maternal hypertensive disease, frequently develop severe perinatal complications in their subsequent pregnancy. |
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Authors:
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Annemieke C Evers; Bas B van Rijn; Maartje M van Rossum; Hein W Bruinse |
Publication Detail:
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Type: Journal Article Date: 2010-09-06 |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 30 ISSN: 1525-6065 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: England |
Other Details:
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Languages: eng Pagination: 37-44 Citation Subset: IM |
Affiliation:
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Division of Perinatology and Gynaecology, University Medical Centre Utrecht, Utrecht, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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