Document Detail

Subselective intra-arterial chemotherapy infusion in the treatment of hepatocellular carcinoma.
MedLine Citation:
PMID:  20494699     Owner:  NLM     Status:  MEDLINE    
Intra-arterial delivery of chemotherapy is a well-established dominant treatment for hepatocellular carcinoma (HCC). This approach takes advantage of differential blood supply to the cancer, which is arterial, and to the liver, which is predominantly portal. Randomized trials demonstrating survival benefit have used transarterial chemoembolization (TACE) with arrest of blood flow and arterial obstruction to increase efficiency of drug delivery. Treatment-associated morbidity is significant but usually justified by the patient benefit. A number of alternative embolic particles have been explored to address efficacy and toxicity deficiencies of the original technology. In this article we list those materials. We then develop evidence that sub-selective arterial infusion therapy without embolic agents provides equivalent efficacy with less treatment morbidity.
John R Daniels; Melissa Wallman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in oncology     Volume:  37     ISSN:  1532-8708     ISO Abbreviation:  Semin. Oncol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420432     Medline TA:  Semin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department of Medicine, Division of Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
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MeSH Terms
Antineoplastic Agents / administration & dosage*,  adverse effects
Carcinoma, Hepatocellular / drug therapy*
Embolization, Therapeutic / methods
Infusions, Intra-Arterial* / methods
Liver Neoplasms / drug therapy*
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Antineoplastic Agents

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