Document Detail

Subregions of human MT complex revealed by comparative MEG and direct electrocorticographic recordings.
MedLine Citation:
PMID:  15294208     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To locate the visual motion complex (MT+) and study its response properties in an epilepsy surgery patient. METHODS: A 17-year-old epilepsy patient underwent invasive monitoring with subdural electrodes in the right temporo-parieto-occipital area. MT+ was investigated by cortical electric stimulation and by epicortical visual evoked potentials time-locked to motion onset of sinusoidal gratings (motion VEP). Motion-related visual evoked magnetic field (motion VEF) was also recorded before the electrode implantation to complement the invasive recording. RESULTS: Motion VEPs revealed two subregions within MT+, generating early and late potentials respectively. The early activity with a peak around 130 ms was localized at a single electrode situated immediately caudal to the initial portion of the ascending limb of the superior temporal sulcus (AL-STS). The late activity, peaking at 242-274 ms, was located ventro-rostrally over three electrodes. Among the four electrodes with motion VEPs, cortical stimulation at the most caudal pair elicited motion-in-depth perception involving the whole visual field. In addition to two subregions revealed on the gyral crown, magnetoencephalography (MEG) demonstrated another subregion with a late motion VEF in AL-STS immediately rostral to the electrode with the early motion VEP. CONCLUSIONS: In combination with MEG recording, the present invasive exploration demonstrated human MT+ in a focal area of the temporo-parieto-occipital junction and delineated possible three subregions as indicated by the different latencies and distributions of the motion VEP/VEFs. SIGNIFICANCE: Comparative MEG and direct electrocorticographic recordings delineated possible subregions within the human MT complex.
R Matsumoto; A Ikeda; T Nagamine; M Matsuhashi; S Ohara; J Yamamoto; K Toma; N Mikuni; J Takahashi; S Miyamoto; H Fukuyama; H Shibasaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  115     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-05     Completed Date:  2004-10-04     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2056-65     Citation Subset:  IM    
Human Brain Research Center, Kyoto University Graduate School of Medicine, Shogoin, Sakyo, Kyoto 606-8507, Japan.
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MeSH Terms
Electric Stimulation
Electrodes, Implanted
Epilepsy, Complex Partial / physiopathology
Evoked Potentials, Visual / physiology*
Motion Perception / physiology*
Parietal Lobe / physiology
Subdural Space
Temporal Lobe / physiology
Visual Cortex / physiology*

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