Document Detail


Subpopulations of sympathetic neurones differ in their sensitivity to nerve growth factor antiserum.
MedLine Citation:
PMID:  4075099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sympathetic postganglionic nerve fibres supplying mesenteric arteries and intrinsic ileal neurones differ in their characteristics of regeneration. Since the latter population of neurones occurs predominantly in prevertebral ganglia, which have been reported to be spared to some extent after treatment with antiserum to nerve growth factor (anti-NGF), we have investigated whether the two populations were differentially sensitive to anti-NGF. Newborn rats were treated daily for the first postnatal week with either anti-NGF or 154 mM NaCl solution. At 4 and 8 weeks of age, the presence of a functional sympathetic innervation to the mesenteric arteries and the gut was determined and correlated with the fluorescence histochemical demonstration of noradrenergic fibres. At both ages, stimulation of extrinsic sympathetic fibres caused an inhibition of gut motility, while the mesenteric arteries completely lacked a sympathetic innervation. Retrograde labelling of nerve cell bodies in control and antiserum treated rats confirmed that the sympathetic neurones supplying the ileal neurones were located in the prevertebral, superior mesenteric and coeliac ganglia and in the splanchnic ganglia lying along the greater splanchnic nerves. By interference from retrograde labelling in control animals, sympathetic neurones supplying the mesenteric arteries were present in all these ganglia, as well as in the thoracic and lumbar paravertebral sympathetic chains. The results suggest that two functionally distinct populations of sympathetic neurones, which overlap considerably in their distributions, are differentially sensitive to the immunological postnatal removal of NGF.
Authors:
C E Hill; I A Hendry; M C Ngu; D F van Helden
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  355     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-01-28     Completed Date:  1986-01-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  121-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Catecholamines / metabolism
Ileum / innervation*
Immune Sera / pharmacology*
Mesenteric Arteries / innervation*
Myenteric Plexus / physiology
Nerve Growth Factors / physiology*
Rats
Rats, Inbred Strains
Submucous Plexus / physiology
Sympathetic Nervous System / physiology*
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Immune Sera; 0/Nerve Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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