| Subpopulations of fetal-like gingival fibroblasts: characterisation and potential significance for wound healing and the progression of periodontal disease. | |
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MedLine Citation:
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PMID: 8957929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Wound healing in the adult is commonly compromised by excessive scar formation. In contrast, fetal wound healing is a regenerative process characterised by the conspicuous absence of scarring. Available evidence suggests that phenotypic differences between fetal and adult fibroblasts are important determinants of these distinct modes of tissue repair. In this context, a number of groups (including our own) have documented differences between fetal and adult fibroblasts with respect to such potentially relevant characteristics as migratory activity, motogenic response to cytokines and the synthesis of motility factors, cytokines and matrix macromolecules. The oral mucosa appears to be a privileged site in the adult in that it continues to display a fetal-like mode of wound healing. Data are presented in this review indicating that a subpopulation of gingival fibroblasts expresses several 'fetal-like' phenotypic characteristics. These observations are discussed in terms of both the continued expression of a fetal-like mode of wound healing in the oral mucosa and the possible differential involvement of distinct fibroblast subpopulations in the progression of periodontal disease. |
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Authors:
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S L Schor; I Ellis; C R Irwin; J Banyard; K Seneviratne; C Dolman; A D Gilbert; D M Chisholm |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Oral diseases Volume: 2 ISSN: 1354-523X ISO Abbreviation: Oral Dis Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-12-31 Completed Date: 1996-12-31 Revised Date: 2010-09-01 |
Medline Journal Info:
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Nlm Unique ID: 9508565 Medline TA: Oral Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 155-66 Citation Subset: D |
Affiliation:
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Department of Dental Surgery and Periodontology, Dental School, University of Dundee, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Cell Count Cell Movement / physiology Cicatrix Connective Tissue / physiology Cytokines / biosynthesis, physiology Disease Progression Fetus / cytology, physiology Fibroblasts / physiology* Gingiva / cytology*, physiology, physiopathology Growth Substances / physiology Humans Hyaluronic Acid / biosynthesis Mouth Mucosa / cytology Periodontal Diseases / pathology, physiopathology* Periodontium / cytology, physiology, physiopathology Phenotype Skin / cytology Wound Healing / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Growth Substances; 0/migration stimulating factor, human; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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