Document Detail


Subpopulations of fetal-like gingival fibroblasts: characterisation and potential significance for wound healing and the progression of periodontal disease.
MedLine Citation:
PMID:  8957929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Wound healing in the adult is commonly compromised by excessive scar formation. In contrast, fetal wound healing is a regenerative process characterised by the conspicuous absence of scarring. Available evidence suggests that phenotypic differences between fetal and adult fibroblasts are important determinants of these distinct modes of tissue repair. In this context, a number of groups (including our own) have documented differences between fetal and adult fibroblasts with respect to such potentially relevant characteristics as migratory activity, motogenic response to cytokines and the synthesis of motility factors, cytokines and matrix macromolecules. The oral mucosa appears to be a privileged site in the adult in that it continues to display a fetal-like mode of wound healing. Data are presented in this review indicating that a subpopulation of gingival fibroblasts expresses several 'fetal-like' phenotypic characteristics. These observations are discussed in terms of both the continued expression of a fetal-like mode of wound healing in the oral mucosa and the possible differential involvement of distinct fibroblast subpopulations in the progression of periodontal disease.
Authors:
S L Schor; I Ellis; C R Irwin; J Banyard; K Seneviratne; C Dolman; A D Gilbert; D M Chisholm
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Oral diseases     Volume:  2     ISSN:  1354-523X     ISO Abbreviation:  Oral Dis     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-12-31     Completed Date:  1996-12-31     Revised Date:  2010-09-01    
Medline Journal Info:
Nlm Unique ID:  9508565     Medline TA:  Oral Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  155-66     Citation Subset:  D    
Affiliation:
Department of Dental Surgery and Periodontology, Dental School, University of Dundee, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Cell Count
Cell Movement / physiology
Cicatrix
Connective Tissue / physiology
Cytokines / biosynthesis,  physiology
Disease Progression
Fetus / cytology,  physiology
Fibroblasts / physiology*
Gingiva / cytology*,  physiology,  physiopathology
Growth Substances / physiology
Humans
Hyaluronic Acid / biosynthesis
Mouth Mucosa / cytology
Periodontal Diseases / pathology,  physiopathology*
Periodontium / cytology,  physiology,  physiopathology
Phenotype
Skin / cytology
Wound Healing / physiology*
Chemical
Reg. No./Substance:
0/Cytokines; 0/Growth Substances; 0/migration stimulating factor, human; 9004-61-9/Hyaluronic Acid

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