Document Detail


Subpopulations of B lymphocytes in germinal centers, II. A germinal center B cell subpopulation expresses sIgD and CD23.
MedLine Citation:
PMID:  2527814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To understand B cell development in germinal centers, it is important to delineate the expression of surface antigens among germinal center cells. Because it is unclear whether germinal center cells express common antigens such as sIgD and CD23, we studied their expression among tonsillar lymphocytes with flow cytometry, immunohistochemistry, and in vitro stimulation. Upon studying a large number of tonsils with flow cytometry, we found that occasional tonsils have a very large number of sIgD+ cells among their PNA+ cells. Furthermore, the occasional tonsils with a large number of sIgD+ and PNA+ cells also have many CD23+ cells among their PNA+ cells. Tonsil sections stained immunohistochemically revealed germinal centers containing sIgD+ cells. In addition, PNA- and sIgD+ cells can be induced to express PNA binding sites in vitro without losing the expression of sIgD. Taking these findings together, we conclude that a subpopulation of germinal center B cells coexpresses sIgD and CD23.
Authors:
M H Nahm; P A Takes; M B Bowen; K A Macke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunology letters     Volume:  21     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-29     Completed Date:  1989-09-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  201-8     Citation Subset:  IM    
Affiliation:
Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.
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MeSH Terms
Descriptor/Qualifier:
Antigens, Differentiation, B-Lymphocyte / immunology*
Antigens, Surface / immunology
B-Lymphocytes / classification*
Cell Separation
Flow Cytometry
Humans
Immunoenzyme Techniques
Immunoglobulin D / immunology*
Palatine Tonsil / immunology*
Receptors, Fc / immunology*
Receptors, IgE
Rosette Formation
Grant Support
ID/Acronym/Agency:
AI-15353/AI/NIAID NIH HHS; AI-19676/AI/NIAID NIH HHS; HL-7038/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Differentiation, B-Lymphocyte; 0/Antigens, Surface; 0/Immunoglobulin D; 0/Receptors, Fc; 0/Receptors, IgE

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