| The subplate and early cortical circuits. | |
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MedLine Citation:
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PMID: 20201645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The developing mammalian cerebral cortex contains a distinct class of cells, subplate neurons (SPns), that play an important role during early development. SPns are the first neurons to be generated in the cerebral cortex, they reside in the cortical white matter, and they are the first to mature physiologically. SPns receive thalamic and neuromodulatory inputs and project into the developing cortical plate, mostly to layer 4. Thus SPns form one of the first functional cortical circuits and are required to relay early oscillatory activity into the developing cortical plate. Pathophysiological impairment or removal of SPns profoundly affects functional cortical development. SPn removal in visual cortex prevents the maturation of thalamocortical synapses, the maturation of inhibition in layer 4, the development of orientation selective responses and the formation of ocular dominance columns. SPn removal also alters ocular dominance plasticity during the critical period. Therefore, SPns are a key regulator of cortical development and plasticity. SPns are vulnerable to injury during prenatal stages and might provide a crucial link between brain injury in development and later cognitive malfunction. |
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Authors:
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Patrick O Kanold; Heiko J Luhmann |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annual review of neuroscience Volume: 33 ISSN: 1545-4126 ISO Abbreviation: Annu. Rev. Neurosci. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-24 Completed Date: 2011-01-27 Revised Date: 2012-04-23 |
Medline Journal Info:
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Nlm Unique ID: 7804039 Medline TA: Annu Rev Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 23-48 Citation Subset: IM |
Affiliation:
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Department of Biology, University of Maryland, College Park, Maryland 20742, USA. pkanold@umd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebral Cortex / cytology, embryology*, growth & development*, physiopathology Humans Neural Pathways / cytology, embryology, growth & development, physiopathology Neuronal Plasticity / physiology Neurons / cytology, pathology, physiology Stem Cells / cytology, pathology, physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 DC009607/DC/NIDCD NIH HHS; R01 DC009607-02/DC/NIDCD NIH HHS; R01 DC009607-04/DC/NIDCD NIH HHS; R01DC009607/DC/NIDCD NIH HHS; R21DC009454/DC/NIDCD NIH HHS |
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