| Suboptimal vitamin D levels in pregnant women despite supplement use. | |
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MedLine Citation:
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PMID: 21913590 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: Obtaining adequate vitamin D during pregnancy is important for the health of mother and child. Low circulating 25-hydroxyvitamin D (25OHD) concentrations, a measure of vitamin D status, have been reported in pregnant women in several countries; yet, there are few studies of pregnant Canadian women. We measured 25OHD concentrations in a multi-ethnic group of pregnant women living in Vancouver (49 degrees N) and explored the determinants of 25OHD. METHODS: 336 pregnant women (16-47 y) between 20 and 35 weeks gestation provided a blood sample and completed questionnaires. RESULTS: Mean 25OHD was 67 (95% CI 64-69) nmol/L. Only 1% of women had a 25OHD concentration indicative of severe deficiency (<25 nmol/L). However, 24% and 65% of women were vitamin D insufficient based on cut-offs of 50 and 75 nmol/L, respectively. In multivariate analysis, mean 25OHD concentrations were 12 nmol/L higher in the summer compared to in winter. Women of European (White) ethnicity had a 9-13 nmol/L higher mean 25OHD concentration than women from other ethnic groups. Almost 80% of women took vitamin D-containing supplements containing > or = 400 IU/d. However, 24% and 65% of these women had 25OHD <50 and <75 nmol/L, respectively. CONCLUSION: Vitamin D insufficiency was not uncommon in this group of pregnant women. Season and ethnicity were determinants of 25OHD but the magnitude of their effect was not large. Most women took vitamin D-containing supplements but this did not provide much protection against insufficiency. Consideration should be given to increasing the amount of vitamin D in prenatal supplements. |
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Authors:
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Wangyang Li; Timothy J Green; Sheila M Innis; Susan I Barr; Susan J Whiting; Antonia Shand; Peter von Dadelszen |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian journal of public health. Revue canadienne de santé publique Volume: 102 ISSN: 0008-4263 ISO Abbreviation: Can J Public Health Publication Date: 2011 Jul-Aug |
Date Detail:
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Created Date: 2011-09-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372714 Medline TA: Can J Public Health Country: Canada |
Other Details:
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Languages: eng Pagination: 308-12 Citation Subset: IM |
Affiliation:
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Department of Food, Nutrition & Health, University of British Columbia, Vancouver, BC. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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