Document Detail

Submaximal exercise in emphysema and malnutrition at two levels of carbohydrate and fat intake.
MedLine Citation:
PMID:  2793699     Owner:  NLM     Status:  MEDLINE    
Eight malnourished patients with emphysema (EMPH) and eight malnourished patients without evidence of lung disease (MLAN) received an infusion of 5% dextrose plus electrolytes (D5W) for 48 h and were then randomly assigned to a hypercaloric diet with either 53% of the calories as carbohydrate (CB) or with 55% as fat (FB) for the 1st wk, maintaining a constant protein intake. The alternate diet was given the following week. Ventilation and gas exchange were measured during supine cycle ergometry at 0, 12, and 25 W during the D5W, CB, and FB diet periods. At each exercise intensity, the EMPH group demonstrated a 12-15% greater O2 consumption, a lower respiratory quotient, and an O2 debt larger than that of the MALN group. Resting ventilation was higher during the CB than FB regimen in both groups of patients, but during the CB diet the EMPH group had a more exaggerated ventilatory response than the MALN group. The results demonstrate that EMPH patients have an unusual metabolic pattern during hypercaloric feeding and exercise. Furthermore in EMPH patients a FB regimen does not appear to create the additional stress on the respiratory system during exercise that is generated with a CB regimen.
S A Goldstein; J Askanazi; D H Elwyn; B Thomashow; J Milic-Emili; V Kvetan; C Weissman; J M Kinney
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  67     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-11-21     Completed Date:  1989-11-21     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1048-55     Citation Subset:  IM    
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
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MeSH Terms
Dietary Carbohydrates / administration & dosage,  metabolism
Dietary Fats / administration & dosage,  metabolism
Emphysema / diet therapy,  physiopathology,  therapy*
Middle Aged
Nutrition Disorders / diet therapy,  physiopathology,  therapy*
Oxygen Consumption
Pulmonary Gas Exchange
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats

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