Document Detail


Submandibular gland biopsy for the diagnosis of Parkinson disease.
MedLine Citation:
PMID:  23334596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical diagnosis of Parkinson disease (PD) is incorrect in 30% or more of subjects particularly at the time of symptom onset. Because Lewy-type α-synucleinopathy is present in the submandibular glands of PD patients, we assessed the feasibility of submandibular gland biopsy for diagnosing PD. We performed immunohistochemical staining for Lewy-type α-synucleinopathy in sections of large segments (simulating open biopsy) and needle cores of submandibular glands from 128 autopsied and neuropathologically classified subjects, including 28 PD, 5 incidental Lewy body disease, 5 progressive supranuclear palsy (3 with concurrent PD), 3 corticobasal degeneration, 2 multiple system atrophy, 22 Alzheimer disease with Lewy bodies, 16 Alzheimer disease without Lewy bodies, and 50 normal elderly. Immunoreactive nerve fibers were present in large submandibular gland sections of all 28 PD subjects (including 3 that also had progressive supranuclear palsy); 3 Alzheimer disease with Lewy bodies subjects were also positive, but none of the other subjects were positive. Cores from frozen submandibular glands taken with 18-gauge needles (total length, 15-38 mm; between 10 and 118 sections per subject examined) were positive for Lewy-type α-synucleinopathy in 17 of 19 PD patients. These results suggest that biopsy of the submandibular gland may be a feasible means of improving PD clinical diagnostic accuracy. This would be particularly advantageous for subject selection in early-stage clinical trials for invasive therapies or for verifying other biomarker studies.
Authors:
Thomas G Beach; Charles H Adler; Brittany N Dugger; Geidy Serrano; Jose Hidalgo; Jonette Henry-Watson; Holly A Shill; Lucia I Sue; Marwan N Sabbagh; Haruhiko Akiyama;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuropathology and experimental neurology     Volume:  72     ISSN:  1554-6578     ISO Abbreviation:  J. Neuropathol. Exp. Neurol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-03-11     Revised Date:  2014-04-11    
Medline Journal Info:
Nlm Unique ID:  2985192R     Medline TA:  J Neuropathol Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  130-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Biopsy
Brain / pathology
Female
Humans
Lewy Body Disease / pathology
Male
Multiple System Atrophy / pathology
Muscle, Smooth / pathology
Nerve Fibers / pathology
Parkinson Disease / metabolism,  pathology*
Submandibular Gland / metabolism,  pathology*
Supranuclear Palsy, Progressive / pathology
alpha-Synuclein / metabolism
Grant Support
ID/Acronym/Agency:
P30 AG019610/AG/NIA NIH HHS; P30 AG19610/AG/NIA NIH HHS; U24 NS072026/NS/NINDS NIH HHS; U24 NS072026/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/alpha-Synuclein
Comments/Corrections
Comment In:
Mov Disord. 2013 Jun;28(6):734   [PMID:  23720221 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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