Document Detail


Sublingual vs oral immunotherapy for food allergy: identifying the right approach.
MedLine Citation:
PMID:  23009174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of food allergy in developed countries has increased in recent years, escalating the need to find a suitable form of treatment as an alternative to current management, which includes strict avoidance and ready availability of injectable epinephrine (adrenaline). Allergen immunotherapy is currently being studied for use in the treatment of IgE-mediated food allergy to the most common foods, including peanut, tree nut, milk and egg. Two modalities, oral immunotherapy (OIT) and sublingual immunotherapy (SLIT), have shown great promise. Both OIT and SLIT have been able to desensitize subjects to varying degrees, but the two treatment methods differ in doses that can be achieved, duration of treatment, safety profile and ease of use outside the research setting, among other aspects. More research is needed to conclude which mode of treatment is more effective in inducing long-term tolerance with the least amount of serious adverse reactions. However, OIT and SLIT show great promise, and a widespread treatment for food allergy may be within reach.
Authors:
Satya D Narisety; Corinne A Keet
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Drugs     Volume:  72     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2013-03-11     Revised Date:  2013-10-30    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  1977-89     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Division of Pediatric Allergy and Immunology, Johns Hopkins University, Baltimore, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Administration, Sublingual
Allergens / administration & dosage*,  immunology
Desensitization, Immunologic / methods*
Food Hypersensitivity / immunology*,  therapy*
Humans
Immunoglobulin E / immunology
Grant Support
ID/Acronym/Agency:
K23 AI103187/AI/NIAID NIH HHS; K23AI103187/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E
Comments/Corrections

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